Wang Chengzu
Clinical Laboratory, Affiliated Cixi Hospital, Wenzhou Medical University, Zhejiang, People's Republic of China.
J Multidiscip Healthc. 2024 Nov 22;17:5473-5486. doi: 10.2147/JMDH.S493863. eCollection 2024.
Colorectal cancer (CRC) is among the most prevalent malignancies worldwide, with rising incidence and mortality rates presenting substantial public health challenges. Traditional detection methods have inherent limitations, which has led to growing interest in liquid biopsy technologies for the identification of circulating tumor DNA (ctDNA). The aim of this study is to explore the developmental trends and future prospects of ctDNA in colorectal cancer through bibliometric analysis.
This bibliometric analysis examines the literature on ctDNA in CRC from 2004 to 2024, utilizing the Web of Science Core Collection database to identify research trends, key areas of interest, and potential future directions. The R package "bibliometrix" and VOSviewer software were employed for bibliometric analysis and visualization. The analysis encompassed an evaluation of publication volume, contributing authors, influential journals, country and institutional contributions, and citation metrics.
The analysis encompassed a total of 1,054 publications, demonstrating a marked escalation in research activity since 2015. The journal "Cancers" has been identified as the most prolific publisher within this domain. Prominent researchers, including Bardelli A and Sartore-Bianchi A, have made substantial contributions to the field. The United States is the leading country in terms of both publication volume and citation frequency, followed by China and Italy. A keyword analysis identified seven conceptual clusters, with "circulating tumor DNA" and "liquid biopsy" emerging as predominant themes.
This study emphasizes the evolving emphasis on the clinical applications of ctDNA, encompassing early detection, treatment monitoring, and prognostic assessment in CRC, thereby underscoring its potential as a non-invasive biomarker in oncology.
结直肠癌（CRC）是全球最常见的恶性肿瘤之一，其发病率和死亡率不断上升，给公共卫生带来了重大挑战。传统检测方法存在固有局限性，这使得人们对用于识别循环肿瘤DNA（ctDNA）的液体活检技术的兴趣日益浓厚。本研究旨在通过文献计量分析探讨ctDNA在结直肠癌中的发展趋势和未来前景。
本文献计量分析考察了2004年至2024年关于CRC中ctDNA的文献，利用科学网核心合集数据库来确定研究趋势、关键关注领域和潜在的未来方向。使用R包“bibliometrix”和VOSviewer软件进行文献计量分析和可视化。分析包括对发表量、贡献作者、有影响力的期刊、国家和机构贡献以及引用指标的评估。
该分析共涵盖1054篇出版物，表明自2015年以来研究活动显著增加。期刊《Cancers》被确定为该领域发表量最多的期刊。包括巴尔德利A和萨托雷 - 比安基A在内的杰出研究人员对该领域做出了重大贡献。美国在发表量和引用频率方面均领先，其次是中国和意大利。关键词分析确定了七个概念集群，其中“循环肿瘤DNA”和“液体活检”成为主要主题。
本研究强调了对ctDNA临床应用的关注度不断演变，包括在CRC中的早期检测、治疗监测和预后评估，从而突出了其作为肿瘤学中非侵入性生物标志物的潜力。
