Bi Chengming, Zhang Lanjun, Liu Jingya, Chen Lianhong
College of Food Science and Technology, Southwest Minzu University, Chengdu, China.
Front Nutr. 2024 Nov 12;11:1450284. doi: 10.3389/fnut.2024.1450284. eCollection 2024.
Hyperuricemia (HUA) is a metabolic disease arising from abnormal purine metabolism. It contributes to an increased risk of kidney damage. The present study aimed to investigate the uric acid (UA)-lowering effects of 259 isolated from yak yogurt and explore its underlying mechanisms. Our results revealed that 259 decreased the UA levels in rats and inhibited the serum activities of xanthine oxidase. In addition, 259 reduced the levels of pro-inflammatory cytokines (tumor necrosis factor (TNF)-, interleukin (IL)-1β, and IL-6) in the kidney and altered the expressions of UA transporters (ABC transporter 2 (ABCG2), PDZ domain containing 1 (PDZK1), urate transporter 1 (URAT1), and sodium-phosphate cotransporter type 4 (NPT4)) to near normal levels. Moreover, it increased the abundance of beneficial bacteria in the gut and recovered the gut microbiota composition, promoting the production of short-chain fatty acids (SCFAs). These findings suggested that 259 can potentially be used to decrease UA levels, repair kidney damage, regulate gut microbiota, and alleviate HUA.
高尿酸血症（HUA）是一种由嘌呤代谢异常引起的代谢性疾病。它会增加肾脏损伤的风险。本研究旨在探讨从牦牛酸奶中分离出的259对降低尿酸（UA）的作用，并探究其潜在机制。我们的结果显示，259可降低大鼠的尿酸水平，并抑制黄嘌呤氧化酶的血清活性。此外，259降低了肾脏中促炎细胞因子（肿瘤坏死因子（TNF）-、白细胞介素（IL）-1β和IL-6）的水平，并将尿酸转运蛋白（ABC转运蛋白2（ABCG2）、含PDZ结构域蛋白1（PDZK1）、尿酸转运蛋白1（URAT1）和钠-磷酸盐共转运体4（NPT4））的表达改变至接近正常水平。此外，它增加了肠道中有益菌的丰度，恢复了肠道微生物群组成，促进了短链脂肪酸（SCFAs）的产生。这些发现表明，259有可能用于降低尿酸水平、修复肾脏损伤、调节肠道微生物群以及缓解高尿酸血症。
