Bentestuen Morten, Sylvest Camilla, Frandsen Anna Poulsgaard, Zacho Helle D
Department of Gynecology and Obstetrics, Aalborg University Hospital, Aalborg, Denmark.
Department of Pathology, Aalborg University Hospital, Aalborg, Denmark.
Clin Nucl Med. 2025 Mar 1;50(3):e178-e179. doi: 10.1097/RLU.0000000000005586. Epub 2024 Nov 27.
A 67-year-old woman presented with a 12 × 20 × 24-cm adnexal tumor. Ultrasonography revealed an irregular, multilocular tumor, with increased flow in the solid components, and ascites-features that are consistent with ovarian cancer. The patient underwent 18 F-FDG PET/CT and 68 Ga-FAPI-46 PET/CT, both of which showed low uptake values. Histopathology confirmed ovarian clear cell adenocarcinoma (OCCC), a less common subtype that is underrepresented in FAPI PET/CT studies so far. Low 18 F-FDG uptake is a known feature of OCCC and has been previously reported; however, this case identifies OCCC as a potential pitfall in 68 Ga-FAPI-46 PET/CT.
一名67岁女性出现一个12×20×24厘米的附件肿瘤。超声检查显示为一个不规则的多房性肿瘤，实性成分血流增加，伴有腹水，这些特征与卵巢癌相符。该患者接受了18F-FDG PET/CT和68Ga-FAPI-46 PET/CT检查，两者均显示摄取值较低。组织病理学证实为卵巢透明细胞腺癌（OCCC），这是一种较罕见的亚型，在目前的FAPI PET/CT研究中代表性不足。18F-FDG摄取低是OCCC的一个已知特征，此前已有报道；然而，该病例表明OCCC在68Ga-FAPI-46 PET/CT中可能是一个潜在的陷阱。
