Department of Psychiatry, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
J Psychosom Obstet Gynaecol. 2024 Dec;45(1):2431814. doi: 10.1080/0167482X.2024.2431814. Epub 2024 Nov 27.
This study aimed to investigate the association between depressive symptoms and pregnancy losses, as well as the moderating effects of demographic variables, including age, income level and ethnicity.
Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9) questionnaire, with key variables such as "loss of interest," "feeling down," and "sleep disturbances." Weighted linear regression models evaluated the relationship between depressive symptoms and pregnancy losses, while interaction analyses explored the moderating effects of demographic factors.
The findings revealed a significant positive association between depressive symptoms and pregnancy losses. Severe symptoms, particularly "thoughts of self-harm" ( .013), were strongly linked to multiple losses. Other symptoms such as "feeling down" ( .001) and "feeling bad about oneself" ( .001) were also significantly associated. The association was most pronounced among women aged 35-50. Additionally, the effect of depressive symptoms was more significant among low-income and minority women, suggesting socioeconomic and cultural factors play a role.
Depression, especially major depression, is significantly associated with an increased number of pregnancy losses, particularly among women aged 35-50. Socioeconomic and cultural factors are influential, highlighting the need for targeted interventions in high-risk groups.
本研究旨在探讨抑郁症状与妊娠丢失之间的关联，以及年龄、收入水平和种族等人口统计学变量的调节作用。
使用患者健康问卷-9（PHQ-9）问卷评估抑郁症状，关键变量包括“兴趣丧失”、“情绪低落”和“睡眠障碍”。加权线性回归模型评估了抑郁症状与妊娠丢失之间的关系，而交互分析则探讨了人口统计学因素的调节作用。
研究结果显示，抑郁症状与妊娠丢失之间存在显著正相关。严重的症状，特别是“自残念头”（.013），与多次流产密切相关。其他症状，如“情绪低落”（.001）和“自我感觉不好”（.001）也与妊娠丢失显著相关。这种关联在 35-50 岁的女性中最为明显。此外，抑郁症状的影响在低收入和少数族裔女性中更为显著，表明社会经济和文化因素发挥了作用。
抑郁，尤其是重度抑郁，与妊娠丢失次数的增加显著相关，尤其是在 35-50 岁的女性中。社会经济和文化因素具有影响力，这突出表明需要在高风险群体中进行有针对性的干预。
