Urology department. Complexo Hospitalario Universitario A Coruña, Spain.
Radiology department. Complexo Hospitalario Universitario A Coruña, Spain.
Magnes Res. 2024 Nov 1;37(2):76-80. doi: 10.1684/mrh.2024.0529.
This prospective case-control study explored the association between urinary magnesium levels and acute urinary retention (AUR) in individuals presenting to the emergency department. Forty-six participants, comprising 23 cases and 23 age- and sex-matched controls, underwent urine analysis for magnesium, calcium, and creatinine concentrations. The exclusion criteria mitigated potential confounding factors. AUR cases exhibited significantly lower magnesium (5.97 vs.3.87, p = 0.031), calcium (11.04 vs. 5.3, p = 0.022), and creatinine (149.9 vs. 66.0, p = 0.005) levels (mg/dL) compared to controls. After adjusting for creatinine levels, no intergroup differences were observed. An inverse linear correlation was noted between the International Prostate Symptom Score and magnesium level (R2 = 0.15, p = 0.009). A magnesium cut-off of 3.57 mg/dL demonstrated 82.6 % sensitivity, 56.5 % specificity, and an AUC of 0.70. Patients with magnesium levels below 3.57 mg/dL had an 80 % higher risk of AUR (OR: 1.80, 95 % CI: 1.08-3.01, p = 0.016). This study highlights urinary magnesium as a potential marker for risk of AUR, paving the way for larger prospective studies in this intriguing domain. Future interventions that manipulate magnesium levels may offer innovative avenues for managing lower urinary tract disorders.
这项前瞻性病例对照研究探讨了在急诊科就诊的个体中尿镁水平与急性尿潴留（AUR）之间的关联。46 名参与者，包括 23 例病例和 23 名年龄和性别匹配的对照者，进行了尿液镁、钙和肌酐浓度分析。排除标准减轻了潜在的混杂因素。AUR 病例的镁（5.97 与 3.87，p=0.031）、钙（11.04 与 5.3，p=0.022）和肌酐（149.9 与 66.0，p=0.005）水平显著低于对照组。在校正肌酐水平后，两组间无差异。国际前列腺症状评分与镁水平呈负线性相关（R2=0.15，p=0.009）。镁水平截断值为 3.57mg/dL 时，灵敏度为 82.6%，特异性为 56.5%，AUC 为 0.70。镁水平低于 3.57mg/dL 的患者 AUR 风险增加 80%（OR：1.80，95%CI：1.08-3.01，p=0.016）。这项研究强调了尿镁作为 AUR 风险的潜在标志物，为这一有趣领域的更大前瞻性研究铺平了道路。未来操纵镁水平的干预措施可能为管理下尿路疾病提供创新途径。
