Bian Hege, Zhang Yuzhong, Liu Kun
Supply Chain Department, Hefei BOE Hospital, Hefei, Anhui, 230013, China.
Department of Surgery, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, 230061, China.
Sci Rep. 2025 Sep 1;15(1):32193. doi: 10.1038/s41598-025-17962-7.
Overactive bladder (OAB) is a common condition that significantly affects quality of life. Magnesium deficiency may influence muscle and nerve functions, potentially contributing to bladder dysfunction. This study aimed to examine whether magnesium depletion is associated with OAB symptoms among U.S. adults. We analyzed data from 28,621 participants aged 20-80 years in the National Health and Nutrition Examination Survey (NHANES) 2005-2018. OAB symptoms were assessed using a standardized questionnaire, and magnesium depletion was evaluated using a magnesium depletion score (MgDS). Logistic regression models adjusted for demographic, lifestyle, and clinical factors were employed to explore the association. Higher MgDS was significantly associated with an increased risk of OAB. In the fully adjusted model, each one-point increase in MgDS was linked to 9% higher odds of OAB (OR = 1.09, 95% CI 1.03-1.15, p = 0.002). Compared to the low MgDS group, individuals in the middle MgDS group had 17% higher odds of OAB (OR = 1.17, 95% CI 1.03-1.33, p = 0.02), while those in the high MgDS group had 20% higher odds (OR = 1.20, 95% CI 1.05-1.38, p = 0.01). Subgroup analyses indicated that this association was particularly pronounced in females, non-smokers, middle-aged adults (40-60 years), and individuals with obesity (BMI ≥ 30 kg/m). Our findings suggest that magnesium depletion is associated with increased OAB risk in U.S. adults; however, due to the cross-sectional nature of this study, causality cannot be inferred and further prospective studies are needed.
膀胱过度活动症（OAB）是一种常见病症，严重影响生活质量。镁缺乏可能影响肌肉和神经功能，有可能导致膀胱功能障碍。本研究旨在探讨镁缺乏是否与美国成年人的OAB症状相关。我们分析了2005 - 2018年美国国家健康与营养检查调查（NHANES）中28,621名年龄在20 - 80岁的参与者的数据。使用标准化问卷评估OAB症状，使用镁缺乏评分（MgDS）评估镁缺乏情况。采用针对人口统计学、生活方式和临床因素进行调整的逻辑回归模型来探讨这种关联。较高的MgDS与OAB风险增加显著相关。在完全调整模型中，MgDS每增加1分，OAB的患病几率就会高出9%（OR = 1.09，95% CI 1.03 - 1.15，p = 0.002）。与低MgDS组相比，中MgDS组个体患OAB的几率高出17%（OR = 1.17，95% CI 1.03 - 1.33，p = 0.02），而高MgDS组个体的患病几率高出20%（OR = 1.20，95% CI 1.05 - 1.38，p = 0.01）。亚组分析表明，这种关联在女性、非吸烟者、中年成年人（40 - 60岁）以及肥胖个体（BMI≥30 kg/m²）中尤为明显。我们的研究结果表明，镁缺乏与美国成年人OAB风险增加相关；然而，由于本研究的横断面性质，无法推断因果关系，需要进一步开展前瞻性研究。
