免疫功能正常儿童的新型隐球菌相关性肺隐球菌病

Pulmonary cryptococcosis associated with Cryptococcus neoformans in an immunocompetent child.

作者信息

Xiao Jiying, Chen Jie, Chen Junsong, Zhang Li, Ali Kamran, Wu Suling

机构信息

Department of Pulmonology, Hangzhou Children's Hospital, Hangzhou, Zhejiang, People's Republic of China.

Department of Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, People's Republic of China.

出版信息

Pediatr Pulmonol. 2025 Jan;60(1):e27368. doi: 10.1002/ppul.27368. Epub 2024 Nov 27.

DOI:10.1002/ppul.27368

PMID:39601496

Abstract

We report a pediatric case of pulmonary cryptococcosis caused by Cryptococcus neoformans in an immunocompetent child. Although the patient presented with mild clinical symptoms, pulmonary imaging revealed severe abnormalities. The diagnosis was confirmed through fungal culture of bronchoalveolar lavage fluid and detection of serum cryptococcal antigen. An appropriate and adequately administered course of antifungal treatment led to a favorable prognosis.

摘要

我们报告了一例免疫功能正常儿童由新型隐球菌引起的肺隐球菌病的儿科病例。尽管该患者临床症状较轻，但肺部影像学显示严重异常。通过支气管肺泡灌洗液体的真菌培养和血清隐球菌抗原检测确诊。适当且充分的抗真菌治疗疗程带来了良好的预后。