Tayeb Faris J, Felemban Mohammed Fareed, Adnan Ashour Amal, Shafie Alaa
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, Taif, Saudi Arabia.
Crit Rev Anal Chem. 2024 Nov 27:1-31. doi: 10.1080/10408347.2024.2433005.
Paraquat (PQ) is a potent and widely utilized herbicide known for its effectiveness in controlling a broad spectrum of weeds. Its chemical properties make it an invaluable tool in agriculture, where it helps maintain crop yields and manage invasive plant species. However, despite its benefits in weed management, PQ poses significant risks due to its severe toxicity, which affects multiple organ systems in both humans and animals. The dual nature of PQ, as both a valuable agricultural chemical and a hazardous toxicant, necessitates a comprehensive understanding of its toxicological impacts and the development of effective detection and development strategies. This review aims to provide a comprehensive overview of PQ-induced toxicities, including neurotoxicity, lung toxicity, liver toxicity, kidney toxicity, and immunotoxicity. By synthesizing current knowledge on PQ health impacts, highlighting epidemiological trends, and exploring recent advancements in colorimetric and fluorimetric detection methods, this review seeks to contribute to the development of strategies for improving public health outcomes and enhancing our ability to manage the risks associated with PQ exposure. Addressing PQ toxicity through a multidisciplinary approach, incorporating toxicological, epidemiological, and technological perspectives, is essential for safeguarding health and promoting effective interventions.
百草枯（PQ）是一种强效且广泛使用的除草剂，以其有效控制多种杂草而闻名。其化学特性使其成为农业中一种非常宝贵的工具，有助于维持作物产量并管理入侵植物物种。然而，尽管PQ在杂草管理方面有诸多益处，但因其具有严重毒性，会影响人和动物的多个器官系统，所以存在重大风险。PQ兼具宝贵的农用化学品和危险毒物的双重性质，这就需要全面了解其毒理学影响，并制定有效的检测和应对策略。本综述旨在全面概述PQ所致的毒性，包括神经毒性、肺毒性、肝毒性、肾毒性和免疫毒性。通过综合当前关于PQ对健康影响的知识、突出流行病学趋势以及探索比色法和荧光检测方法的最新进展，本综述旨在为改善公共卫生结果的策略制定做出贡献，并增强我们管理与PQ暴露相关风险的能力。通过多学科方法应对PQ毒性，融合毒理学、流行病学和技术视角，对于保障健康和促进有效干预至关重要。
