慢性肾衰竭大鼠残余肾模型的局限性：缺乏草酸钙组织损伤。
Limitations of the rat remnant kidney model of chronic renal failure: absence of calcium oxalate tissue injury.
作者信息
Hoffman G S, Reed R G, Guiney W B, Wells E E, Oldroyd N O
出版信息
Nephron. 1986;42(4):330-4. doi: 10.1159/000183697.
We have studied the rat remnant kidney model as a tool to assess the impact of secondary oxalosis on renal failure. Although the plasma of uremic rats demonstrated increased levels of oxalic acid, deposits of oxalate crystals in tissue were not observed. The absence of such deposits in the remnant kidney, as well as other tissues, may be due to a lesser degree of hyperoxalemia observed in the rat compared to man or may reflect that uremic deaths among the experimental animals occurred prior to formation of detectable calcium oxalate deposition. We conclude that the rat remnant kidney is not a suitable model to study the impact of uremic oxalosis in man.
我们已研究了大鼠残余肾模型，将其作为评估继发性草酸中毒对肾衰竭影响的一种工具。尽管尿毒症大鼠的血浆显示草酸水平升高，但未观察到组织中有草酸盐晶体沉积。残余肾以及其他组织中不存在此类沉积物，可能是因为与人类相比，大鼠中观察到的高草酸血症程度较低，或者可能反映出实验动物中的尿毒症死亡发生在可检测到草酸钙沉积形成之前。我们得出结论，大鼠残余肾不是研究人类尿毒症草酸中毒影响的合适模型。
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