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剖宫产术与出生和儿童时期血液 DNA 甲基化：妊娠和儿童期表观遗传学联盟中的荟萃分析。

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium.

机构信息

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

出版信息

Sci Adv. 2024 Nov 29;10(48):eadr2084. doi: 10.1126/sciadv.adr2084. Epub 2024 Nov 27.

DOI:10.1126/sciadv.adr2084
PMID:39602535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11601205/
Abstract

Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, < 1.0 × 10): (cg19423175), (cg01500140), (cg13917614), (cg18247172), (cg22348356), and (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery's molecular influence on offspring health.

摘要

与阴道分娩出生的婴儿相比，经剖宫产分娩的婴儿患代谢、免疫和神经发育障碍的风险更高，尽管其机制尚不清楚。我们进行了一项基于全基因组关联研究的荟萃分析，以研究分娩方式与出生时血液 DNA 甲基化及其在儿童早期的持续性之间的关联。参与者来自 19 个妊娠队列（9833 名足月新生儿）和 6 个儿科队列（2429 名 6 至 10 岁的儿童）。我们在脐带血中鉴定出与剖宫产相关的 6 个 CpG（效应大小范围：0.4%至 0.7%，<1.0×10）： （cg19423175）、 （cg01500140）、 （cg13917614）、 （cg18247172）、 （cg22348356）和 （cg20674490），独立于细胞比例和其他混杂因素。在儿童时期，这些 CpG 均与剖宫产无关，也未鉴定出其他 CpG。分娩方式与出生时的细胞比例有关，但与儿童时期无关。需要进一步的研究来阐明剖宫产对后代健康的分子影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/1a435e3cccc1/sciadv.adr2084-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/64ec356d5ecc/sciadv.adr2084-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/1188c199ebab/sciadv.adr2084-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/fdf53c41c294/sciadv.adr2084-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/1a435e3cccc1/sciadv.adr2084-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/64ec356d5ecc/sciadv.adr2084-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/1188c199ebab/sciadv.adr2084-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/fdf53c41c294/sciadv.adr2084-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f09/11601205/1a435e3cccc1/sciadv.adr2084-f4.jpg

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Newborn differential DNA methylation and subcortical brain volumes as early signs of severe neurodevelopmental delay in a South African Birth Cohort Study.南非出生队列研究中新生儿 DNA 甲基化差异与皮质下脑体积作为严重神经发育迟缓的早期标志物。
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