Ponce P, Carvalho F, Coelho A
Nephrologie. 1986;7(1):25-7.
Fine-needle aspiration of subcutaneous fat (FNAF) was performed in 24 patients, 12 with previously diagnosed amyloidosis presenting with proteinuria or nephrotic syndrome, and 12 presenting a nephrotic syndrome without amyloidosis on renal biopsy. FNAF was positive in 10 of 12 patients with amyloidosis (sensitivity: 83%) and negative in 12 of 12 patients with non-amyloid nephrotic syndrome (specificity: 100%). Considering a 2.5 to 10% prevalence of amyloidosis in adult patients with proteinuria or nephrotic syndrome, a positive FNAF is diagnostic of amyloidosis, and a negative FNAF rules out the diagnosis with a probability of 98 to 99%. FNAF is a simple and safe method which can be useful in patients who cannot undergo a renal biopsy.
对24例患者进行了皮下脂肪细针抽吸术（FNAF），其中12例先前诊断为淀粉样变性且伴有蛋白尿或肾病综合征，另外12例肾活检显示为无淀粉样变性的肾病综合征。在12例淀粉样变性患者中，10例FNAF呈阳性（敏感性：83%）；在12例非淀粉样变性肾病综合征患者中，12例FNAF呈阴性（特异性：100%）。考虑到蛋白尿或肾病综合征成年患者中淀粉样变性的患病率为2.5%至10%，FNAF阳性可诊断为淀粉样变性，FNAF阴性排除诊断的概率为98%至99%。FNAF是一种简单、安全的方法，对无法进行肾活检的患者可能有用。
