François B, Trolliet P, Cahen R, Semet M P
Nephrologie. 1986;7(1):9-12.
In 59 out of 80 patients with recurrent renal calcium stones studied between 1977 and 1982 and followed up for 4,5 to 7 years, an index has been used to determine the activity of the disease, before and after treatment with diet, high water intake, thiazide and/or allopurinol. As estimated by variations of the "activity index", the treatment was effective in all groups studied: patients with idiopathic hypercalciuria were prescribed a low purine and oxalate diet and a large water intake associated or not with thiazide; hyperuricosuric patients were treated by the same diet and allopurinol; patients with no metabolic abnormality were submitted to diet and/or thiazide and/or allopurinol. The association of thiazide and allopurinol seems to be a more effective therapy in recurrent stone formers with primary hyperoxaluria than high diuresis and succinimide.
在1977年至1982年间研究的80例复发性肾钙结石患者中，有59例随访了4.5至7年，采用一种指标来确定疾病的活动度，该指标在饮食、高饮水量、噻嗪类药物和/或别嘌呤醇治疗前后进行评估。根据“活动指数”的变化估计，治疗对所有研究组均有效：特发性高钙尿症患者采用低嘌呤和草酸盐饮食，并大量饮水，可联合或不联合噻嗪类药物；高尿酸尿症患者采用相同饮食和别嘌呤醇治疗；无代谢异常的患者接受饮食和/或噻嗪类药物和/或别嘌呤醇治疗。对于原发性高草酸尿症的复发性结石形成者，噻嗪类药物和别嘌呤醇联合使用似乎比高利尿和琥珀酰亚胺更有效。
