Jungers P, Lacour B, Daniel J, Chauveau P, Bruneau M, Bailly M
Nephrologie. 1984;5(5):202-4.
Because of the close relation between sodium (Na) and calcium (Ca) tubular reabsorption, restriction of sodium intake has been proposed in hypercalciuric stone formers. We simultaneously measured urinary concentrations of both ions in 30 recurrent stone formers (19 male, 11 female, mean age 40,8 +/- 10,2 years) with fasting hypercalciuria, before and after reduction of calciuria using long-term thiazide (TZ) treatment associated with moderate restriction of calcium intake, without concomitant Na restriction. No recurrence of stones was observed in this group with a 12 to 49 month follow-up. UCa strongly correlated with UNa in both conditions. However, UCa significantly decreased with TZ (128 +/- 32 vs 73 +/- 26 mumol/kg/day, p less than 0.001), whereas neither UNaV (190 +/- 60 vs 202 +/- 57 mmol/day) nor diuresis significantly varied. We conclude that calciuria can be lowered without reduction in Na intake in hypercalciuric stone formers controlled by thiazide treatment.
由于钠（Na）和钙（Ca）的肾小管重吸收之间存在密切关系，因此有人提出对高钙尿性结石形成者限制钠摄入。我们同时测量了30例复发性结石形成者（19例男性，11例女性，平均年龄40.8±10.2岁）空腹高钙尿时以及使用长期噻嗪类药物（TZ）治疗并适度限制钙摄入但不限制钠摄入来降低钙尿前后两种离子的尿浓度。在12至49个月的随访中，该组未观察到结石复发。在两种情况下，尿钙（UCa）均与尿钠（UNa）密切相关。然而，使用TZ后UCa显著降低（128±32 vs 73±26 μmol/kg/天，p<0.001），而UNaV（190±60 vs 202±57 mmol/天）和尿量均无显著变化。我们得出结论，在噻嗪类药物治疗控制的高钙尿性结石形成者中，不减少钠摄入也可降低钙尿。
