Aporti F, Borsato R, Calderini G, Rubini R, Toffano G, Zanotti A, Valzelli L, Goldstein L
Neurobiol Aging. 1986 Mar-Apr;7(2):115-20. doi: 10.1016/0197-4580(86)90149-1.
During aging, male Sprague-Dawley rats display increasing frequency of bursts of seizure-like EEG patterns. They also have a decreased retention of passive avoidance response and a loss of spontaneous alternation in a Y maze. A study was made on the effects of chronic administration of phosphatidylserine in aged rats. It was found that BC-PS reduced by 65% the number of seizures, and by 70% their duration. It also facilitated retention of passive avoidance and of spontaneous alteration behavior. These results suggest that phosphatidylserine can affect electrophysiological and behavioral parameters in aged rats probably by counteracting age-related biochemical changes.
在衰老过程中，雄性斯普拉格-道利大鼠出现癫痫样脑电图模式爆发的频率增加。它们在被动回避反应中的记忆保持能力下降，并且在Y迷宫中自发交替行为丧失。对老年大鼠长期给予磷脂酰丝氨酸的效果进行了一项研究。结果发现，BC-PS可使癫痫发作次数减少65%，发作持续时间减少70%。它还促进了被动回避和自发交替行为的记忆保持。这些结果表明，磷脂酰丝氨酸可能通过抵消与年龄相关的生化变化来影响老年大鼠的电生理和行为参数。
