Klein B G, Mooney R D, Fish S E, Rhoades R W
Neuroscience. 1986;17(1):57-78. doi: 10.1016/0306-4522(86)90225-3.
Intracellular recording and horseradish peroxidase injection techniques were used to structurally and functionally characterize the striate cortical neurons in hamster that projected to the superior colliculus and/or lateral posterior nucleus of the thalamus. With two exceptions, the receptive field properties and morphological characteristics of the neurons antidromically activated from the colliculus and lateral posterior nucleus were quite similar. Striate corticotectal and striate cortico-lateral posterior neurons generally had non-oriented receptive fields which gave either "on-off' or no responses to flashed stimuli. Only a small number (less than 5%) were orientation selective, but about one-third were directionally selective. Most of the cells preferred movement with an upward component. Most striate corticotectal and cortico-lateral posterior cells responded to a wide range of stimulus velocities and exhibited little spatial summation. With the possible exception of two cells, all the projection neurons we recovered were large lamina V pyramidal cells whose apical dendrites extended to and branched extensively in layer I. All had extensive (in some cases over 1 mm) tangential axon collaterals, primarily in layers V and/or VI. The electrophysiological experiments also demonstrated that some (50% of a sample of 20 cells) corticotectal neurons also sent an axon collateral to the lateral posterior nucleus. Finally, our recordings showed that many (56% of a sample of 27 neurons) cells which could be antidromically activated from the lateral posterior nucleus, but not the superior colliculus had response latencies which exceeded those of almost all the cells which could be antidromically activated from the tectum. Retrograde transport of diamidino yellow and true blue confirmed the electrophysiological result that individual cortical neurons projected to both the superior colliculus and lateral posterior nucleus. These experiments showed that 20% of the striate cortical cells that projected into colliculus also sent an axon collateral to the lateral posterior nucleus.
采用细胞内记录和辣根过氧化物酶注射技术，对仓鼠视皮层中投射至上丘和/或丘脑外侧后核的神经元进行结构和功能特征分析。除两个例外情况外，由上丘和外侧后核逆向激活的神经元的感受野特性和形态特征非常相似。视皮层-上丘和视皮层-丘脑外侧后神经元通常具有非定向性感受野，对闪光刺激产生“开-关”或无反应。只有少数（不到5%）具有方向选择性，但约三分之一具有运动方向选择性。大多数细胞偏好向上运动的成分。大多数视皮层-上丘和视皮层-丘脑外侧后细胞对广泛的刺激速度有反应，且几乎没有空间总和现象。除了两个细胞可能例外，我们所记录到的所有投射神经元均为大的V层锥体细胞，其顶端树突延伸至I层并在该层广泛分支。所有细胞都有广泛的（在某些情况下超过1毫米）切向轴突侧支，主要分布在V层和/或VI层。电生理实验还表明，一些（20个细胞样本中的50%）视皮层-上丘神经元也发出轴突侧支至丘脑外侧后核。最后，我们的记录显示，许多（27个神经元样本中的56%）可由丘脑外侧后核逆向激活但不能由上丘逆向激活的细胞，其反应潜伏期超过了几乎所有可由上丘逆向激活的细胞。二脒基黄和真蓝的逆行运输证实了电生理结果，即单个皮层神经元投射至上丘和丘脑外侧后核。这些实验表明，投射至上丘的视皮层细胞中有20%也发出轴突侧支至丘脑外侧后核。
