采用微/纳米技术增强的药物递送系统的3D打印

3D printing of drug delivery systems enhanced with micro/nano-technology.

作者信息

Zhu Hui, Kuang Huijuan, Huang Xinxin, Li Xiao, Zhao Ruosen, Shang Guojin, Wang Ziyu, Liao Yucheng, He Jiankang, Li Dichen

机构信息

State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, PR China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an 710049, PR China; State Industry-Education Integration Center for Medical Innovations, Xi'an Jiaotong University, Xi'an 710049, PR China.

出版信息

Adv Drug Deliv Rev. 2025 Jan;216:115479. doi: 10.1016/j.addr.2024.115479. Epub 2024 Nov 26.

DOI:10.1016/j.addr.2024.115479

PMID:39603388

Abstract

Drug delivery systems (DDSs) are increasingly important in ensuring drug safety and enhancing therapeutic efficacy. Micro/nano-technology has been utilized to develop DDSs for achieving high stability, bioavailability, and drug efficiency, as well as targeted delivery; meanwhile, 3D printing technology has made it possible to tailor DDSs with diverse components and intricate structures. This review presents the latest research progress integrating 3D printing technology and micro/nano-technology for developing novel DDSs. The technological fundamentals of 3D printing technology supporting the development of DDSs are presented, mainly from the perspective of different 3D printing mechanisms. Distinct types of DDSs leveraging 3D printing and micro/nano-technology are analyzed deeply, featuring micro/nanoscale materials and structures to enrich functionalities and improve effectiveness. Finally, we will discuss the future directions of 3D-printed DDSs integrated with micro/nano-technology, focusing on technological innovation and clinical application. This review will support interdisciplinary research efforts to advance drug delivery technology.

摘要

药物递送系统（DDSs）在确保药物安全性和提高治疗效果方面日益重要。微纳技术已被用于开发DDSs，以实现高稳定性、生物利用度和药物效率，以及靶向递送；与此同时，3D打印技术使定制具有不同成分和复杂结构的DDSs成为可能。本文综述了将3D打印技术与微纳技术相结合用于开发新型DDSs的最新研究进展。介绍了支持DDSs开发的3D打印技术的技术基础，主要从不同的3D打印机制角度进行阐述。深入分析了利用3D打印和微纳技术的不同类型的DDSs，其特点是具有微纳尺度的材料和结构，以丰富功能并提高有效性。最后，我们将讨论与微纳技术集成的3D打印DDSs的未来发展方向，重点关注技术创新和临床应用。本文综述将支持跨学科研究工作，以推动药物递送技术的发展。