Tetsuo Aki, Muto Megumi, Yokomine Masato, Kashiwada Hironobu, Horinouchi Takashi, Yoshizato Toshiyuki, Tsuda Naotake
Department of Obstetrics and Gynecology, Kurume University School of Medicine.
Department of Obstetrics and Gynecology, St. Mary's Hospital.
Kurume Med J. 2025 Aug 1;71(1.2):43-49. doi: 10.2739/kurumemedj.MS7112008. Epub 2024 Nov 27.
This study aimed to explore the clinical characteristics of umbilical cord cysts (UCCs) detected from the second trimester onwards in a single tertiary center over a 22-year period. The subjects consisted of a total of 12 cases of UCCs among 11 pregnant women (10 singleton pregnancies and 1 twin pregnancy), diagnosed at ≥ 14 weeks of gestation, and managed at Kurume University Hospital from 2000 to 2021. The maternal backgrounds, characteristics of the cysts, including their location, numbers, sizes, associated fetal/neonatal findings, and outcomes, were analyzed retrospectively. The median maternal age was 28 years, with diagnosis at 18.5 gestational weeks. Cysts were found near the umbilical ring (8 cases), in a free loop (3 cases), and in both of these locations (1 case). Single cysts appeared in 8 cases, and multiple cysts in 4 cases, with the median diameter being 25.0 mm. Sizes varied by gestation, being larger near the umbilical ring without correlation to cyst number. Among the 9 cases with cysts located near the umbilical ring, 5 cases had fetal abnormalities, including trisomy 18 (2 cases), Beckwith-Wiedeman syndrome (1), and intrauterine fetal death (1). Urachal remnants were found in 4 cases and omphalomesenteric duct remnants in 1 case after birth. When UCC is observed, particularly a cyst located near the umbilical ring, comprehensive fetal ultrasound screening is necessary, and attention should be paid to fetal anomalies that may coexist. In cases where these are not identified prenatally, the presence of conditions such as urachal remnants needs to be considered.
本研究旨在探讨在一家三级中心22年期间从孕中期开始检测到的脐带囊肿（UCCs）的临床特征。研究对象包括11名孕妇中的12例UCCs（10例单胎妊娠和1例双胎妊娠），诊断孕周≥14周，于2000年至2021年在久留米大学医院接受治疗。对产妇背景、囊肿特征（包括位置、数量、大小、相关胎儿/新生儿表现及结局）进行回顾性分析。产妇年龄中位数为28岁，诊断孕周为18.5周。囊肿位于脐环附近（8例）、游离袢内（3例）以及这两个位置均有（1例）。单囊肿出现8例，多囊4例，中位数直径为25.0mm。大小随孕周变化，在脐环附近较大，与囊肿数量无关。在9例囊肿位于脐环附近的病例中，5例有胎儿异常，包括18三体（2例）、贝克威思-维德曼综合征（1例）和胎儿宫内死亡（1例）。出生后发现4例脐尿管残余和1例卵黄管残余。当观察到UCC时，尤其是位于脐环附近的囊肿，需要进行全面的胎儿超声筛查，并应注意可能并存的胎儿异常。在产前未发现这些异常的情况下，需要考虑脐尿管残余等情况的存在。
