Pisa M, Szechtman H
Neurosci Lett. 1986 Feb 14;64(1):41-6. doi: 10.1016/0304-3940(86)90660-9.
A new behavioral test afforded the original demonstration of a compulsive and extremely lateralized taxis for edges in a minority (16%) of rats treated with the dopamine (DA) receptor agonist apomorphine (APO) (1.25 mg/kg, s.c.). APO also induced a reliable lateralization of locomotor direction in a rotometer in 29% of rats. The lateralizing effects of the drug on taxis for edges and rotational direction were not reliably associated, however, suggesting that these effects of APO are independent of each other. Interhemispheric asymmetries of DA receptors in functionally distinctive brain regions may underlie the diverse lateralizing effects of APO in subpopulations of rats.
一种新的行为测试首次证明，在少数（16%）接受多巴胺（DA）受体激动剂阿扑吗啡（APO）（1.25毫克/千克，皮下注射）治疗的大鼠中，存在对边缘的强迫性且极度偏向一侧的趋性。APO还在29%的大鼠中诱导了旋转仪中运动方向的可靠偏向。然而，药物对边缘趋性和旋转方向的偏向作用并不可靠相关，这表明APO的这些作用是相互独立的。功能不同的脑区中DA受体的半球间不对称可能是APO在大鼠亚群中产生不同偏向作用的基础。
