Pisa M, Szechtman H
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):525-31. doi: 10.1016/0278-5846(85)90012-0.
Subcutaneous injections of apomorphine, a dopamine receptor agonist, induced a lateralization of taxis for edges in 16% of rats and a reliable lateralization of postural support in 82% of rats. The relation among these effects and the lateralizing effects of apomorphine on rotational behavior were examined. Lateralized rotation did not reliably correlate with lateralized taxis. However, it correlated with a relatively large asymmetry of postural support. The lateralizing effects of apomorphine on taxis and rotation may reflect attentional and directional asymmetries, respectively. It is proposed that apomorphine can induce different types of lateralizations, including attentional, postural and directional, and that the lateralizing effects of apomorphine on posture and locomotor direction are interrelated. Regional brain interhemispheric asymmetries in the responsiviness of dopamine receptors may underlie different types of apomorphine-induced lateralizations.
皮下注射多巴胺受体激动剂阿扑吗啡后，16%的大鼠出现了对边缘的趋性偏侧化，82%的大鼠出现了可靠的姿势支撑偏侧化。研究了这些效应与阿扑吗啡对旋转行为的偏侧化效应之间的关系。偏侧化旋转与偏侧化趋性并无可靠的相关性。然而，它与姿势支撑的相对较大不对称性相关。阿扑吗啡对趋性和旋转的偏侧化效应可能分别反映了注意力和方向不对称性。有人提出，阿扑吗啡可诱导不同类型的偏侧化，包括注意力、姿势和方向偏侧化，且阿扑吗啡对姿势和运动方向的偏侧化效应相互关联。多巴胺受体反应性的区域脑半球间不对称可能是不同类型阿扑吗啡诱导偏侧化的基础。
