分解免疫球蛋白A：嗜免疫托马氏菌揭示微生物群与免疫的相互作用。
Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.
作者信息
Sutherland Duncan B, Kato Lucia M, Fagarasan Sidonia
机构信息
Ludwig Group, Environmental Engineering Institute, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
出版信息
Trends Immunol. 2024 Dec;45(12):928-930. doi: 10.1016/j.it.2024.11.003. Epub 2024 Nov 27.
The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.
陆及其同事最近发现了一种能降解IgA的细菌——嗜免疫托马氏菌，这为微生物对黏膜免疫的影响以及进化过程中的免疫权衡提供了见解。通过调节IgA滴度，嗜免疫托马氏菌影响宿主与病原体之间的动态相互作用和平衡。这对免疫健康、微生物组研究和治疗学都有影响。
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