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肾上腺嗜酸性细胞瘤:一种罕见的表现为18F-氟脱氧葡萄糖PET摄取阳性的良性男性化肾上腺肿瘤。

Adrenal oncocytoma: a rare presentation of a benign 18 F-fluorodeoxyglucose PET avid virilising adrenal tumour.

作者信息

Lee Danielle, Green Jonathan, Crane James, Taylor David R, Reynolds Saira, Ng Wen, Jacob Koshy, Whitelaw Benjamin, Aylwin Simon, Galata Gabriele, Lewis Dylan, Seager Matthew

机构信息

King's College Hospital NHS Foundation Trust, .

Faculty of Life Sciences and Medicine, King's College London.

出版信息

Nucl Med Commun. 2025 Apr 1;46(4):367-372. doi: 10.1097/MNM.0000000000001932. Epub 2024 Nov 28.

DOI:10.1097/MNM.0000000000001932
PMID:39604271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11878579/
Abstract

A woman in her 70s presented with features of hyperandrogenism including clitoral enlargement and deepening of her voice. Biochemical investigations revealed raised plasma androgens and urinary androgen metabolites and imaging findings showed a highly F-18 fluorodeoxyglucose (FDG)-PET avid left adrenal tumour initially suspected to be a malignant adrenocortical carcinoma (ACC). She subsequently underwent an uncomplicated laparoscopic adrenalectomy where complete resection of her tumour was achieved. Histopathological analysis demonstrated a benign adrenal oncocytoma with no evidence of malignancy. This case illustrates a rare presentation of a functioning virilising adrenal oncocytoma as a benign mimic of ACC.

摘要

一名70多岁的女性出现了高雄激素血症的特征,包括阴蒂增大和声音变低沉。生化检查显示血浆雄激素和尿雄激素代谢产物升高,影像学检查发现左肾上腺肿瘤对F-18氟脱氧葡萄糖(FDG)-PET摄取高度增高,最初怀疑是恶性肾上腺皮质癌(ACC)。她随后接受了一次顺利的腹腔镜肾上腺切除术,肿瘤得以完整切除。组织病理学分析显示为良性肾上腺嗜酸性细胞瘤,无恶性证据。该病例说明了一种罕见的情况,即功能性男性化肾上腺嗜酸性细胞瘤表现为ACC的良性模仿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/06e250ba5f13/nmc-46-367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/3509fabcf907/nmc-46-367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/ca3faed09c76/nmc-46-367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/33096bed9543/nmc-46-367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/06e250ba5f13/nmc-46-367-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/3509fabcf907/nmc-46-367-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/ca3faed09c76/nmc-46-367-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/33096bed9543/nmc-46-367-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/558e/11878579/06e250ba5f13/nmc-46-367-g004.jpg

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本文引用的文献

1
Incidental Adrenal Masses: A Case Report of an Adrenal Oncocytoma.偶发性肾上腺肿块:一例肾上腺嗜酸性细胞瘤病例报告
Cureus. 2023 Oct 30;15(10):e47994. doi: 10.7759/cureus.47994. eCollection 2023 Oct.
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Prognosis of Adrenal Oncocytic Neoplasms (AONs): Literature Review of 287 Cases and Presentation of the Oldest Patient.肾上腺嗜酸细胞瘤(AONs)的预后:287例文献综述及最年长患者病例报告
J Clin Med. 2023 Nov 4;12(21):6925. doi: 10.3390/jcm12216925.
3
Adrenocortical carcinoma: Diagnosis, prognostic classification and treatment of localized and advanced disease.
肾上腺皮质癌:局限性和晚期疾病的诊断、预后分类和治疗。
Cancer Treat Res Commun. 2023;37:100759. doi: 10.1016/j.ctarc.2023.100759. Epub 2023 Sep 8.
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The new histological system for the diagnosis of adrenocortical cancer.新版肾上腺皮质癌的组织学诊断系统。
Front Endocrinol (Lausanne). 2023 Jul 24;14:1218686. doi: 10.3389/fendo.2023.1218686. eCollection 2023.
5
European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors.欧洲内分泌学会与欧洲肾上腺肿瘤研究网络合作制定的关于肾上腺意外瘤处理的临床实践指南。
Eur J Endocrinol. 2023 Jul 20;189(1):G1-G42. doi: 10.1093/ejendo/lvad066.
6
The Diagnostic Value of 18F-FDG PET/CT Scan in Characterizing Adrenal Tumors.18F-FDG PET/CT 扫描对肾上腺肿瘤特征的诊断价值。
J Clin Endocrinol Metab. 2023 Aug 18;108(9):2435-2445. doi: 10.1210/clinem/dgad138.
7
Case Report: Adrenocortical Oncocytoma in a Patient with a Previous Contralateral Adrenalectomy for a Cortisol-Secreting Adenoma.病例报告:一名曾因分泌皮质醇腺瘤接受对侧肾上腺切除术的患者发生肾上腺皮质嗜酸细胞瘤。
Front Surg. 2022 May 19;9:897967. doi: 10.3389/fsurg.2022.897967. eCollection 2022.
8
Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.《2022 年世界卫生组织肾上腺皮质肿瘤分类概述》。
Endocr Pathol. 2022 Mar;33(1):155-196. doi: 10.1007/s12022-022-09710-8. Epub 2022 Mar 14.
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A Clinical Challenge: Endocrine and Imaging Investigations of Adrenal Masses.临床挑战:肾上腺肿块的内分泌和影像学检查。
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