Lee Danielle, Green Jonathan, Crane James, Taylor David R, Reynolds Saira, Ng Wen, Jacob Koshy, Whitelaw Benjamin, Aylwin Simon, Galata Gabriele, Lewis Dylan, Seager Matthew
King's College Hospital NHS Foundation Trust, .
Faculty of Life Sciences and Medicine, King's College London.
Nucl Med Commun. 2025 Apr 1;46(4):367-372. doi: 10.1097/MNM.0000000000001932. Epub 2024 Nov 28.
A woman in her 70s presented with features of hyperandrogenism including clitoral enlargement and deepening of her voice. Biochemical investigations revealed raised plasma androgens and urinary androgen metabolites and imaging findings showed a highly F-18 fluorodeoxyglucose (FDG)-PET avid left adrenal tumour initially suspected to be a malignant adrenocortical carcinoma (ACC). She subsequently underwent an uncomplicated laparoscopic adrenalectomy where complete resection of her tumour was achieved. Histopathological analysis demonstrated a benign adrenal oncocytoma with no evidence of malignancy. This case illustrates a rare presentation of a functioning virilising adrenal oncocytoma as a benign mimic of ACC.
一名70多岁的女性出现了高雄激素血症的特征,包括阴蒂增大和声音变低沉。生化检查显示血浆雄激素和尿雄激素代谢产物升高,影像学检查发现左肾上腺肿瘤对F-18氟脱氧葡萄糖(FDG)-PET摄取高度增高,最初怀疑是恶性肾上腺皮质癌(ACC)。她随后接受了一次顺利的腹腔镜肾上腺切除术,肿瘤得以完整切除。组织病理学分析显示为良性肾上腺嗜酸性细胞瘤,无恶性证据。该病例说明了一种罕见的情况,即功能性男性化肾上腺嗜酸性细胞瘤表现为ACC的良性模仿。