Gallerand Alexandre, Han Jichang, Ivanov Stoyan, Randolph Gwendalyn J
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Université Côte d'Azur, CNRS, LP2M, Nice, France.
Nat Cardiovasc Res. 2024 Dec;3(12):1424-1437. doi: 10.1038/s44161-024-00580-3. Epub 2024 Nov 27.
The past 15 years have witnessed a leap in understanding the life cycle, gene expression profiles, origins and functions of mouse macrophages in many tissues, including macrophages of the artery wall and heart that have critical roles in cardiovascular health. Here, we review the phenotypical and functional diversity of macrophage populations in multiple organs and discuss the roles that proliferation, survival, and recruitment and replenishment from monocytes have in maintaining macrophages in homeostasis and inflammatory states such as atherosclerosis and myocardial infarction. We also introduce emerging data that better characterize the life cycle and phenotypic profiles of human macrophages. We discuss the similarities and differences between murine and human macrophages, raising the possibility that tissue-resident macrophages in humans may rely more on bone marrow-derived monocytes than in mouse.
在过去15年里，人们对小鼠巨噬细胞在许多组织中的生命周期、基因表达谱、起源和功能的理解有了飞跃，包括在心血管健康中起关键作用的动脉壁和心脏巨噬细胞。在此，我们综述了多个器官中巨噬细胞群体的表型和功能多样性，并讨论了增殖、存活以及单核细胞的招募和补充在维持巨噬细胞处于稳态以及动脉粥样硬化和心肌梗死等炎症状态中所起的作用。我们还介绍了能更好地表征人类巨噬细胞生命周期和表型谱的新数据。我们讨论了小鼠和人类巨噬细胞之间的异同，提出人类组织驻留巨噬细胞可能比小鼠更依赖骨髓来源的单核细胞的可能性。
