• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一场超长耐力赛事会导致赛后48小时恢复期循环调节性T细胞、CD4+初始T细胞和CD8+效应记忆T细胞发生变化。

An ultra-endurance event leads to changes in circulating regulatory T-cells, CD4+ naïve and CD8+ effector memory T-cells in the 48 h post-race recovery period.

作者信息

Lithgow Hannah, Gibson Laura, Wilson Russell, Guthrie Neil, Ingram-Sills Lesley, Clifford Tom, Ross Mark

机构信息

School of Energy, Geoscience, Infrastructure and Society, Institute of Life and Earth Sciences, Heriot-Watt University, JMF7, Edinburgh, EH14 4AS, UK.

School of Applied Sciences, Edinburgh Napier University, Edinburgh, UK.

出版信息

Eur J Appl Physiol. 2025 Apr;125(4):1129-1138. doi: 10.1007/s00421-024-05677-y. Epub 2024 Nov 27.

DOI:10.1007/s00421-024-05677-y
PMID:39604770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11950060/
Abstract

PURPOSE

Exercise is known to acutely affect T-lymphocyte populations in the peripheral blood, which is intensity- and duration-dependent. However, effects of longer duration endurance exercise (>5 h) on T-cells in the days following are unknown. The aim of this study was to investigate the circulating T-cell changes that occur in response to an ultra-endurance event, which may provide insight into the inflammatory response to ultra-endurance exercise.

METHODS

Ten individuals (m = 7, f = 3) completing an Ironman 70.3 event volunteered for the study. Peripheral blood samples were taken 1-2 days pre-race (PRE-RACE), and 1 day (RACE + 1) and 2 days (RACE + 2) post-race, with circulating T-cells enumerated by flow cytometry (total CD3+, CD4+ and CD8+ T-cells, regulatory T-cells [CD4+CD25+CD127-; T], naïve [CD27+CD45RA+; NA], central memory [CD27+CD45RA-; CM], effector memory [CD27-CD45RA-; EM], and effector memory CD45RA+ [CD27-CD45RA+; EMRA]).

RESULTS

There were no changes in total CD3+, CD4+ and CD8+ T-cells. T RACE + 1 was significantly higher compared to PRE-RACE, as were the proportion of CD4+ NA cells and CD8+ CM cells at RACE + 2; CD8+ EM cells fell at RACE + 2 (absolute counts and proportion).

CONCLUSION

In conclusion, the ultra-endurance event evoked T-cell changes over the 48 h recovery period, with an increase in T-cells that regulate the immune response, and a reduction in circulating EM T-cells, most likely trafficked to sites of tissue damage and inflammation.

摘要

目的

已知运动能急性影响外周血中的T淋巴细胞群体，且这种影响取决于运动强度和持续时间。然而，持续时间较长的耐力运动（>5小时）在随后几天对T细胞的影响尚不清楚。本研究的目的是调查超耐力赛事后循环T细胞的变化，这可能有助于深入了解对超耐力运动的炎症反应。

方法

十名完成铁人70.3赛事的个体（男性=7名，女性=3名）自愿参与本研究。在赛前1 - 2天（赛前）、赛后1天（赛后+1）和2天（赛后+2）采集外周血样本，通过流式细胞术对循环T细胞进行计数（总CD3 +、CD4 +和CD8 + T细胞、调节性T细胞[CD4 + CD25 + CD127 -；T]、初始T细胞[CD27 + CD45RA +；NA]、中央记忆T细胞[CD27 + CD45RA -；CM]、效应记忆T细胞[CD27 - CD45RA -；EM]和效应记忆CD45RA + T细胞[CD27 - CD45RA +；EMRA]）。

结果

总CD3 +、CD4 +和CD8 + T细胞无变化。赛后+1时T细胞显著高于赛前，赛后+2时CD4 + NA细胞和CD8 + CM细胞的比例也显著高于赛前；赛后+2时CD8 + EM细胞减少（绝对计数和比例）。

结论

总之，超耐力赛事在48小时恢复期内引起了T细胞变化，调节免疫反应的T细胞增加，循环EM T细胞减少，这些细胞很可能迁移到组织损伤和炎症部位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/5f16895bdea9/421_2024_5677_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/09f1e80cdc2d/421_2024_5677_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/7a919de6d9da/421_2024_5677_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/11376d68c984/421_2024_5677_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/5f16895bdea9/421_2024_5677_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/09f1e80cdc2d/421_2024_5677_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/7a919de6d9da/421_2024_5677_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/11376d68c984/421_2024_5677_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a284/11950060/5f16895bdea9/421_2024_5677_Fig4_HTML.jpg

相似文献

1
An ultra-endurance event leads to changes in circulating regulatory T-cells, CD4+ naïve and CD8+ effector memory T-cells in the 48 h post-race recovery period.一场超长耐力赛事会导致赛后48小时恢复期循环调节性T细胞、CD4+初始T细胞和CD8+效应记忆T细胞发生变化。
Eur J Appl Physiol. 2025 Apr;125(4):1129-1138. doi: 10.1007/s00421-024-05677-y. Epub 2024 Nov 27.
2
CD45RA-Foxp3(high) activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28+central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis.类风湿关节炎患者外周血中 CCR7+CD45RA-CD27+CD28+ 中央记忆亚群中 CD45RA-Foxp3(high) 激活/效应调节性 T 细胞减少。
Biochem Biophys Res Commun. 2013 Sep 6;438(4):778-83. doi: 10.1016/j.bbrc.2013.05.120. Epub 2013 Jun 6.
3
Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.与乳糜泻患儿调节性T细胞（Treg）上CD101(+) /CD129(+)高表达形成对比的是，1型糖尿病患儿Treg细胞上CD39(+) /CD45RA(+)表达较低。
Clin Exp Immunol. 2015 Apr;180(1):70-82. doi: 10.1111/cei.12559.
4
The impact of 6-month training preparation for an Ironman triathlon on the proportions of naïve, memory and senescent T cells in resting blood.为期 6 个月的 Ironman 三项全能训练准备对静息血液中幼稚、记忆和衰老 T 细胞比例的影响。
Eur J Appl Physiol. 2012 Aug;112(8):2989-98. doi: 10.1007/s00421-011-2273-9. Epub 2011 Dec 15.
5
Naïve and central memory T-cell lymphopenia in end-stage renal disease.终末期肾病中的初始和中枢记忆性T细胞淋巴细胞减少症。
Kidney Int. 2006 Jul;70(2):371-6. doi: 10.1038/sj.ki.5001550. Epub 2006 May 31.
6
Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.CD8 + 效应记忆T细胞缺陷是多发性硬化症的早期且持续存在的特征。
Mult Scler. 2014 Dec;20(14):1825-32. doi: 10.1177/1352458514536252. Epub 2014 May 19.
7
Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients.类风湿关节炎患者外周血中效应记忆性CD45RA+ CD62L- CD8+ T细胞减少，而中枢记忆性CD45RA- CD62L+ CD8+ T细胞增加。
Arthritis Res Ther. 2003;5(2):R91-6. doi: 10.1186/ar619. Epub 2003 Jan 6.
8
Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment.从儿童期到老年期记忆T细胞的积累：CD4(+)中的中枢和效应记忆细胞与CD8(+)区室中的效应记忆和终末分化记忆细胞。
Mech Ageing Dev. 2006 Mar;127(3):274-81. doi: 10.1016/j.mad.2005.11.001. Epub 2005 Dec 13.
9
Naive and Stem Cell Memory T Cell Subset Recovery Reveals Opposing Reconstitution Patterns in CD4 and CD8 T Cells in Chronic Graft vs. Host Disease.幼稚和干细胞记忆 T 细胞亚群的恢复揭示了慢性移植物抗宿主病中 CD4 和 CD8 T 细胞重建的相反模式。
Front Immunol. 2019 Mar 6;10:334. doi: 10.3389/fimmu.2019.00334. eCollection 2019.
10
Transcriptional Analysis of Total CD8 T Cells and CD8CD45RA Memory T Cells From Young and Old Healthy Blood Donors.年轻和老年健康献血者的总 CD8 T 细胞和 CD8CD45RA 记忆 T 细胞的转录分析。
Front Immunol. 2022 Jan 27;13:806906. doi: 10.3389/fimmu.2022.806906. eCollection 2022.

引用本文的文献

1
Right Ventricular Function Improves After Bench Press: A Speckle Tracking Echocardiography Study.卧推运动后右心室功能改善：一项斑点追踪超声心动图研究。
Medicina (Kaunas). 2025 Aug 15;61(8):1469. doi: 10.3390/medicina61081469.

本文引用的文献

1
Regulatory T cells shield muscle mitochondria from interferon-γ-mediated damage to promote the beneficial effects of exercise.调节性 T 细胞保护肌肉线粒体免受干扰素 -γ 介导的损伤，从而促进运动的有益作用。
Sci Immunol. 2023 Nov 3;8(89):eadi5377. doi: 10.1126/sciimmunol.adi5377.
2
GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.GPR174 敲低通过上调 AREG 表达促进后肢缺血小鼠模型的血流恢复。
Nat Commun. 2022 Dec 6;13(1):7519. doi: 10.1038/s41467-022-35159-8.
3
CD4FoxP3CD73 regulatory T cell promotes cardiac healing post-myocardial infarction.
CD4FoxP3CD73 调节性 T 细胞促进心肌梗死后的心脏愈合。
Theranostics. 2022 Mar 6;12(6):2707-2721. doi: 10.7150/thno.68437. eCollection 2022.
4
Can exercise affect immune function to increase susceptibility to infection?运动是否会影响免疫功能，从而增加感染的易感性？
Exerc Immunol Rev. 2020;26:8-22.
5
Accumulation of Skeletal Muscle T Cells and the Repeated Bout Effect in Rats.骨骼肌 T 细胞的积累和大鼠的重复回合效应。
Med Sci Sports Exerc. 2020 Jun;52(6):1280-1293. doi: 10.1249/MSS.0000000000002256.
6
Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.调节性 T 细胞在创伤愈合过程中的免疫和非免疫介导作用。
Immunology. 2019 Jul;157(3):190-197. doi: 10.1111/imm.13057. Epub 2019 Apr 9.
7
There is limited existing evidence to support the common assumption that strenuous endurance exercise bouts impair immune competency.现有证据有限，无法支持剧烈耐力运动回合会损害免疫能力这一普遍假设。
Expert Rev Clin Immunol. 2019 Feb;15(2):105-109. doi: 10.1080/1744666X.2019.1548933. Epub 2018 Dec 3.
8
Muscle damage and inflammation biomarkers after two ultra-endurance mountain races of different distances: 54 km vs 111 km.两种不同距离的超长耐力山地赛赛后肌肉损伤和炎症生物标志物：54 公里与 111 公里。
Physiol Behav. 2019 Jun 1;205:51-57. doi: 10.1016/j.physbeh.2018.10.002. Epub 2018 Oct 3.
9
β-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans.β-肾上腺素能受体信号转导介导了人类急性运动后 CD8+T 细胞、NK 细胞和非经典单核细胞分化亚群的优先动员。
Brain Behav Immun. 2018 Nov;74:143-153. doi: 10.1016/j.bbi.2018.08.017. Epub 2018 Aug 30.
10
The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury.T淋巴细胞在创伤性和收缩性损伤所致骨骼肌修复中的作用
Front Physiol. 2018 Jun 20;9:768. doi: 10.3389/fphys.2018.00768. eCollection 2018.