术前维生素D水平与瘢痕疙瘩复发之间的关系
The Relationship Between Preoperative Vitamin D Levels and Keloid Recurrence.
作者信息
Lee Da Woon, Kang Daihun, Ha Boram, Kim Da Hye, Chang Choong Hyun, Park Tae Hwan
机构信息
Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea.
出版信息
J Cosmet Dermatol. 2025 Feb;24(2):e16687. doi: 10.1111/jocd.16687. Epub 2024 Nov 28.
BACKGROUND
Keloids, characterized by excessive collagen deposition, often recur despite various treatments. This study explores the association between preoperative serum vitamin D levels and keloid recurrence in a Korean population.
METHODS
A retrospective cohort of 160 patients who underwent keloid excision was analyzed. Preoperative serum 25(OH) vitamin D and 1,25(OH) vitamin D levels were measured. Recurrence rates were compared using hierarchical logistic regression, adjusting for potential confounders.
RESULTS
Age was significantly associated with keloid recurrence (OR: 0.934, p = 0.009), indicating older age was linked to lower recurrence risk. No significant association was found between preoperative 25(OH) vitamin D (p = 0.395) and 1,25(OH) vitamin D levels (p = 0.925) and keloid recurrence.
CONCLUSIONS
Preoperative vitamin D levels do not predict keloid recurrence in this Korean cohort, while age is a significant predictor. Understanding the multifactorial nature of keloid pathogenesis requires further investigation into other potential risk factors.
背景
瘢痕疙瘩以胶原蛋白过度沉积为特征，尽管接受了各种治疗，仍常复发。本研究探讨了韩国人群术前血清维生素D水平与瘢痕疙瘩复发之间的关联。
方法
对160例行瘢痕疙瘩切除术的患者进行回顾性队列分析。测量术前血清25(OH)维生素D和1,25(OH)维生素D水平。使用分层逻辑回归比较复发率，并对潜在混杂因素进行校正。
结果
年龄与瘢痕疙瘩复发显著相关（比值比：0.934，p = 0.009），表明年龄越大，复发风险越低。术前25(OH)维生素D水平（p = 0.395）和1,25(OH)维生素D水平（p = 0.925）与瘢痕疙瘩复发之间未发现显著关联。
结论
在这个韩国队列中，术前维生素D水平不能预测瘢痕疙瘩复发，而年龄是一个显著的预测因素。了解瘢痕疙瘩发病机制的多因素性质需要进一步研究其他潜在风险因素。
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