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耳部瘢痕疙瘩术后单次 9.5 Gy 与 10 Gy 照射的对比分析

A Comparative Analysis of Postoperative Single Fraction of 9.5 Gy Versus 10 Gy for Ear Keloids.

作者信息

Kang Daihun, Ha Boram, Park Tae Hwan

机构信息

Department of Plastic and Reconstructive Surgery, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea.

Department of Radiation Oncology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea.

出版信息

Dermatol Surg. 2025 Feb 1;51(2):185-190. doi: 10.1097/DSS.0000000000004406. Epub 2024 Oct 3.

Abstract

BACKGROUND

The optimal radiotherapy doses for postoperative treatment of ear keloids are currently a topic of debate.

OBJECTIVE

The authors compared the efficacy of 9.5-Gy and 10-Gy single-fraction electron beam radiation therapy after surgical excision and evaluated the impact of radiation timing on outcomes.

MATERIALS AND METHODS

This study was conducted on patients with ear keloid who underwent surgical excision and postoperative electron beam radiotherapy between May 2021 and June 2024. Patients were divided into groups based on radiation dose (9.5 vs 10) and timing (within 8 hours vs 24 hours postoperatively). Recurrence rates and complications were also compared.

RESULTS

The study included 182 patients (21 men and 161 women). The overall recurrence rate was 3.3% (6/182). The 10-Gy group had a significantly lower recurrence rate than the 9.5-Gy group (0.81% vs 8.47%; p = .014). Radiation timing did not significantly influence recurrence rates (2.59% vs 3.80%, p = 1). Complications were not significantly different.

CONCLUSION

A postoperative single dose of 10 Gy is the most effective low-dose single fractional electron beam radiotherapy for preventing ear keloid recurrence. Once administered within 24 hours after surgery, the timing of radiotherapy has no significant impact on treatment outcomes.

摘要

背景

耳部瘢痕疙瘩术后治疗的最佳放疗剂量目前仍是一个有争议的话题。

目的

作者比较了手术切除后9.5 Gy和10 Gy单次分割电子束放射治疗的疗效,并评估了放疗时机对治疗结果的影响。

材料与方法

本研究对2021年5月至2024年6月期间接受手术切除及术后电子束放疗的耳部瘢痕疙瘩患者进行。根据放疗剂量(9.5 Gy与10 Gy)和时机(术后8小时内与术后24小时内)将患者分组。还比较了复发率和并发症。

结果

该研究纳入了182例患者(21例男性和161例女性)。总复发率为3.3%(6/182)。10 Gy组的复发率显著低于9.5 Gy组(0.81%对8.47%;p = 0.014)。放疗时机对复发率无显著影响(2.59%对3.80%,p = 1)。并发症无显著差异。

结论

术后单次给予10 Gy是预防耳部瘢痕疙瘩复发最有效的低剂量单次分割电子束放疗。一旦在术后24小时内给予,放疗时机对治疗结果无显著影响。

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