体力活动与保留比受损肺量计之间的关联：横断面 NHANES 研究。

Associations Between Physical Activity and Preserved Ratio Impaired Spirometry: A Cross-Sectional NHANES Study.

机构信息

The First People's Hospital of Hangzhou Linping District, Zhejiang University School of Medicine Second Affiliated Hospital Linping Hospital, Hangzhou, Zhejiang, People's Republic of China.

Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.

出版信息

Int J Chron Obstruct Pulmon Dis. 2024 Nov 23;19:2517-2528. doi: 10.2147/COPD.S486447. eCollection 2024.

DOI:10.2147/COPD.S486447

PMID:39606713

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11600944/

Abstract

BACKGROUND

Preserved ratio impaired spirometry (PRISm) is considered to be one of the early chronic obstructive pulmonary disease states, and there are few studies on PRISm prevention. We aimed to evaluate the relationship between physical activity and the risk of PRISm.

METHODS

A cross-sectional study was conducted using data from US adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012. We examined the association between physical activity and PRISm using multivariable logistic regression models and a restricted cubic spline (RCS) model.

RESULTS

Compared to the normal and chronic obstructive pulmonary disease (COPD) groups, the PRISm group had lower levels of physical activity (3537.2 MET-min/week in the normal group vs 3452.1 MET-min/week in the COPD group vs 2841.5 MET-min/week in the PRISm group). Adjusted multivariable regression models revealed that greater physical activity dose (more than 4800 MET-min/week) was associated with lower odds of PRISm (adjusted odds ratio [aOR] = 0.77, 95% confidence interval [95% CI] = 0.61-0.98; = 0.031). The RCS curve revealed that there was a significant nonlinear negative dose-response relationship between the level of physical activity and the risk of PRISm ( 0.05). In the population with a body mass index (BMI) ≥25 kg/m, the higher physical activity dose was associated with a significantly lower risk of PRISm (OR = 0.51, 95% CI: 0.46-0.82).

CONCLUSION

A greater total physical activity level was associated with a lower risk of PRISm in US adults, especially in populations with a BMI ≥ 25 kg/m. These findings emphasize that a physically active lifestyle may be a potential precaution against PRISm.

摘要

背景

保留比受损的肺活量测定法（PRISm）被认为是慢性阻塞性肺疾病的早期状态之一，目前关于 PRISm 预防的研究较少。我们旨在评估体力活动与 PRISm 风险之间的关系。

方法

本研究使用了参加 2007 年至 2012 年期间美国国家健康和营养检查调查（NHANES）的美国成年人的数据进行了横断面研究。我们使用多变量逻辑回归模型和限制立方样条（RCS）模型来检查体力活动与 PRISm 之间的关联。

结果

与正常和慢性阻塞性肺疾病（COPD）组相比，PRISm 组的体力活动水平较低（正常组为 3537.2 MET-min/周，COPD 组为 3452.1 MET-min/周，PRISm 组为 2841.5 MET-min/周）。调整后的多变量回归模型显示，较高的体力活动剂量（超过 4800 MET-min/周）与 PRISm 的可能性较低相关（调整后的优势比[aOR] = 0.77，95%置信区间[95%CI] = 0.61-0.98； = 0.031）。RCS 曲线显示，体力活动水平与 PRISm 风险之间存在显著的非线性负剂量反应关系（ 0.05）。在体质指数（BMI）≥25 kg/m2 的人群中，较高的体力活动剂量与 PRISm 的风险显著降低相关（OR = 0.51，95%CI：0.46-0.82）。