Universidade Federal de Goiás - Liga de Hipertensão, Goiânia, GO - Brasil.
Pontifícia Universidade Católica de Goiás - Escola de Ciências Sociais e da Saúde, Goiânia, GO - Brasil.
Arq Bras Cardiol. 2024 Oct;121(11):e20240122. doi: 10.36660/abc.20240122.
Osteoprotegerin (OPG) is a marker of vascular calcification and cardiovascular risk in patients with chronic kidney disease (CKD).
This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those without renal dysfunction.
This case-control study was conducted in a specialized hypertension center in 2022. A total of 79 patients over 18 years of age participated in the study. The case group consisted of 30 patients with moderate renal dysfunction (CKD stage 3) and the control group included 49 individuals with glomerular filtration rate ≥ 60 mL/min/1.73 m2. The significance level adopted in the statistical analysis was 5%.
Central pulse pressure (cPP), PWV, and augmentation index (AIx) were higher in patients with renal dysfunction. The serum OPG level positively correlated with peripheral and central systolic blood pressure, cPP, PWV, and AIx. Conversely, the serum OPG did not correlate with FMD.
OPG and PWV are possible biomarkers of vascular dysfunction that are altered in patients with moderate renal dysfunction. Despite limitations of this study, including that it was a case-control study conducted at a single center, it has the potential, as a proof of concept, to generate the hypothesis of OPG and PWV as biomarkers of early vascular damage in this population.
骨保护素（OPG）是慢性肾脏病（CKD）患者血管钙化和心血管风险的标志物。
本研究旨在比较和分析 3 期 CKD 患者与无肾功能障碍患者的 OPG 值与血流介导的舒张（FMD）和脉搏波速度（PWV）测量值。
本病例对照研究于 2022 年在一家专门的高血压中心进行。共有 79 名年龄在 18 岁以上的患者参与了研究。病例组由 30 名中度肾功能障碍（CKD 第 3 期）患者组成，对照组包括 49 名肾小球滤过率≥60 mL/min/1.73 m2 的患者。在统计分析中采用的显著性水平为 5%。
肾功能障碍患者的中心脉压（cPP）、PWV 和增强指数（AIx）较高。血清 OPG 水平与外周和中心收缩压、cPP、PWV 和 AIx 呈正相关。相反，血清 OPG 与 FMD 不相关。
OPG 和 PWV 可能是血管功能障碍的生物标志物，在中度肾功能障碍患者中发生改变。尽管本研究存在局限性，包括这是一项在单一中心进行的病例对照研究，但它具有作为概念验证的潜力，可以提出 OPG 和 PWV 作为该人群早期血管损伤的生物标志物的假设。
