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Nucleotide sequence analysis of the spacer regions flanking the rat rRNA transcription unit and identification of repetitive elements.大鼠rRNA转录单元侧翼间隔区的核苷酸序列分析及重复元件的鉴定。
Nucleic Acids Res. 1986 Mar 25;14(6):2799-810. doi: 10.1093/nar/14.6.2799.
2
Multiple repeated units in Drosophila melanogaster ribosomal DNA spacer stimulate rRNA precursor transcription.
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Human ribosomal DNA: conserved sequence elements in a 4.3-kb region downstream from the transcription unit.人类核糖体DNA：转录单元下游4.3千碱基区域中的保守序列元件。
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[Structural organization of the non-transcribed spacer of the rat ribosomal repeated sequence].[大鼠核糖体重复序列非转录间隔区的结构组织]
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Binding of sequences from the 5'- and 3'-nontranscribed spacers of the rat rDNA locus to the nucleolar matrix.大鼠核糖体DNA基因座5′-和3′-非转录间隔区序列与核仁基质的结合。
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8
Partial nucleotide sequence of a 3.4 kb fragment from the rat ribosomal DNA nontranscribed spacer.大鼠核糖体DNA非转录间隔区一个3.4 kb片段的部分核苷酸序列
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9
Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes.人类和小鼠核糖体基因转录终止相关序列及因子的进化变化。
Mol Cell Biol. 1987 Jul;7(7):2521-9. doi: 10.1128/mcb.7.7.2521-2529.1987.
10
Natural point mutations within rat rDNA transcription terminator elements reveal the functional importance of single bases for factor binding and termination.大鼠核糖体DNA转录终止元件内的自然点突变揭示了单个碱基对因子结合和终止的功能重要性。
Nucleic Acids Res. 1987 May 26;15(10):4131-43. doi: 10.1093/nar/15.10.4131.

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Characterization of rat ribosomal DNA. The highly repetitive sequences that flank the ribosomal RNA transcription unit are homologous and contain RNA polymerase III transcription initiation sites.大鼠核糖体DNA的特征。位于核糖体RNA转录单元两侧的高度重复序列是同源的，并且包含RNA聚合酶III转录起始位点。
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大鼠rRNA转录单元侧翼间隔区的核苷酸序列分析及重复元件的鉴定。

Nucleotide sequence analysis of the spacer regions flanking the rat rRNA transcription unit and identification of repetitive elements.

作者信息

Yavachev L P, Georgiev O I, Braga E A, Avdonina T A, Bogomolova A E, Zhurkin V B, Nosikov V V, Hadjiolov A A

出版信息

Nucleic Acids Res. 1986 Mar 25;14(6):2799-810. doi: 10.1093/nar/14.6.2799.

DOI:10.1093/nar/14.6.2799
PMID:3960734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC339699/
Abstract

We investigated the organization of the rat rDNA non-transcribed spacer (NTS) by determining the sequence of large NTS segments located upstream (2501 bp) and downstream (4025 bp) from the rRNA transcription unit. We identified four B2-like and two ID mobile elements. They may be grouped in three pairs with the members of each pair located in the upstream and downstream NTS. The ID sequences are identical to the consensus sequence, while the pairs of B2-like elements show 85% and 50/65% homology to the consensus B2 sequence. The proximal part of the downstream NTS contains a region of widely diverged SalI tandem repeats. A considerable part of the analyzed upstream and downstream NTS sequences is constituted by different types of simple sequences and long poly(purine) X poly(pyrimidine) tracts. These data show that the rat rDNA NTS regions flanking the rRNA transcription unit are characterized by a combination of short interspersed (B2-superfamily) and various simple sequences.

摘要

我们通过测定位于rRNA转录单元上游（2501 bp）和下游（4025 bp）的大的非转录间隔区（NTS）片段的序列，研究了大鼠rDNA非转录间隔区的组织情况。我们鉴定出四个B2样元件和两个ID移动元件。它们可以分成三对，每对的成员分别位于上游和下游NTS中。ID序列与共有序列相同，而B2样元件对与共有B2序列的同源性分别为85%和50/65%。下游NTS的近端部分包含一个差异很大的SalI串联重复区域。分析的上游和下游NTS序列的相当一部分由不同类型的简单序列和长的聚嘌呤X聚嘧啶片段组成。这些数据表明，rRNA转录单元两侧的大鼠rDNA NTS区域的特征是短散在元件（B2超家族）和各种简单序列的组合。