脑特异性基因在其内含子中有识别序列。
Brain-specific genes have identifier sequences in their introns.
作者信息
Milner R J, Bloom F E, Lai C, Lerner R A, Sutcliffe J G
出版信息
Proc Natl Acad Sci U S A. 1984 Feb;81(3):713-7. doi: 10.1073/pnas.81.3.713.
The 82-nucleotide identifier (ID) sequence is present in the rat genome in 1-1.5 X 10(5) copies and in cDNA clones of precursors of brain-specific mRNAs. One brain-specific gene contains more than one ID sequence in its introns. There is an excess of ID sequences to brain genes, and some ID sequences appear to have been inserted as mobile elements into other genetic locations. Therefore, brain genes contain ID sequences in their introns, but not all ID sequences are located in brain gene introns. A brain ID consensus sequence has been obtained by comparing 8 ID nucleotide sequences.
82个核苷酸的识别（ID）序列在大鼠基因组中以1 - 1.5×10⁵个拷贝存在，并且存在于脑特异性mRNA前体的cDNA克隆中。一个脑特异性基因在其内含子中包含不止一个ID序列。ID序列相对于脑基因数量过剩，并且一些ID序列似乎已作为可移动元件插入到其他基因位置。因此，脑基因在其内含子中含有ID序列，但并非所有ID序列都位于脑基因内含子中。通过比较8个ID核苷酸序列获得了一个脑ID共有序列。
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