使用二氟氢化钾（KHF）进行金催化的末端炔烃氢氟化反应。
Gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF).
作者信息
Pronovost Raphaël, Rion Mathis, Tzouras Nikolaos V, Nolan Steven P, Paquin Jean-François
机构信息
PROTEO, CCVC, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, G1V 0A6, Canada.
Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S-3, 9000 Ghent, Belgium.
出版信息
Chem Commun (Camb). 2024 Dec 12;60(100):15035-15038. doi: 10.1039/d4cc05049e.
A gold-catalyzed hydrofluorination of terminal alkynes is reported. The salient features of this study showcase the use of potassium bifluoride, KHF, as the fluorinating agent in conjunction with a fluorinated solvent, hexafluoroisopropanol. The reaction is mediated by a well-defined precursor, [Au(IPr)(OH)] with an acid activator. A wide range of functionalized terminal alkynes can be converted to the corresponding monofluoroalkenes in up to 97% yield.
报道了一种金催化的末端炔烃氢氟化反应。该研究的显著特点是使用二氟氢化钾（KHF₂）作为氟化剂，并与氟化溶剂六氟异丙醇配合使用。该反应由一种明确的前体[Au(IPr)(OH)]与酸活化剂介导。多种官能化的末端炔烃可以转化为相应的单氟烯烃，产率高达97%。
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