Pronovost Raphaël, Rion Mathis, Tzouras Nikolaos V, Nolan Steven P, Paquin Jean-François
PROTEO, CCVC, Département de chimie, Université Laval, 1045 avenue de la Médecine, Québec, QC, G1V 0A6, Canada.
Department of Chemistry and Centre for Sustainable Chemistry, Ghent University, Krijgslaan 281, S-3, 9000 Ghent, Belgium.
Chem Commun (Camb). 2024 Dec 12;60(100):15035-15038. doi: 10.1039/d4cc05049e.
A gold-catalyzed hydrofluorination of terminal alkynes is reported. The salient features of this study showcase the use of potassium bifluoride, KHF, as the fluorinating agent in conjunction with a fluorinated solvent, hexafluoroisopropanol. The reaction is mediated by a well-defined precursor, [Au(IPr)(OH)] with an acid activator. A wide range of functionalized terminal alkynes can be converted to the corresponding monofluoroalkenes in up to 97% yield.
报道了一种金催化的末端炔烃氢氟化反应。该研究的显著特点是使用二氟氢化钾（KHF₂）作为氟化剂，并与氟化溶剂六氟异丙醇配合使用。该反应由一种明确的前体[Au(IPr)(OH)]与酸活化剂介导。多种官能化的末端炔烃可以转化为相应的单氟烯烃，产率高达97%。
