Splenomegaly. When and how to treat.

Splenomegaly results from a variety of illnesses that can interfere with normal splenic function. The great number of potential predisposing factors and clinical settings necessitates a thorough history and careful physical examination that includes well-defined laboratory studies. Appropriate therapy covers a broad range, from doing nothing more than periodic follow-up to laparotomy with splenectomy, depending upon the factors involved in the individual case.