Xiangya Nursing School, Central South University, Changsha, China.
Teaching and Research Section of Clinical Nursing, Xiangya Hospital Central South University, Changsha, Hunan, China.
BMJ Open. 2024 Nov 27;14(11):e085981. doi: 10.1136/bmjopen-2024-085981.
Epidemiological literature indicates that sarcopenia (SA) is increasingly prevalent among patients with knee osteoarthritis (KOA). This study aims to provide the pooled prevalence of SA and identify determinant factors associated with SA among patients with KOA.
This systematic review follows Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) auxiliary writing checklist. A thorough literature review and systematic search will be performed using the electronic databases of PubMed, Web of Science, Embase, CNKI and WanFang, covering the period from the earliest records until 11 September 2024. Reference lists of the eligible studies will also be carried out. The search strategy will be based on two main concepts, namely 'knee osteoarthritis' and 'sarcopenia', taking the form of a combination of MeSH terms and entry terms to find literature. Two reviewers will independently evaluate each title and abstract. All observational studies documenting the prevalence of SA and/or associated factors in KOA will be included. The prevalence of SA will be subjected to a single-group meta-analysis using Stata 18.0 software. Pooled prevalence with a 95% CI will be calculated using random effects and quality-effects models. The pooled relative hazards will be calculated using a random-effects Meta-analysis. The main analysis results will include differences in the prevalence of SA in KOA patients by diagnostic criteria, course of KOA, disease status (eg, knee pain, disease duration), physical activity, diagnostic criteria and different geographical contexts. Secondary results may analyse subgroups such as gender and age, and further, a meta-regression analysis will be used to synthesise the factors influencing SA. Sensitivity analyses and heterogeneity between studies and evidence of publication bias will also be assessed.
This review will summarise the prevalence and influencing factors of SA in patients with KOA based on existing evidence. It is expected that the results will identify gaps in knowledge and areas for further research. The review will be submitted for publication in topic specific journals and disseminated to professional networks. Individual patient data are not included, so ethical approval is not required.
CRD42023490539.
流行病学文献表明，肌肉减少症（SA）在膝骨关节炎（KOA）患者中越来越普遍。本研究旨在提供 KOA 患者中 SA 的患病率，并确定与 SA 相关的决定因素。
本系统评价遵循系统评价和荟萃分析的首选报告项目（PRISMA）辅助写作清单。将使用 PubMed、Web of Science、Embase、CNKI 和万方的电子数据库进行全面的文献回顾和系统搜索，涵盖时间从最早的记录到 2024 年 9 月 11 日。还将对合格研究的参考文献进行检索。搜索策略将基于两个主要概念，即“膝骨关节炎”和“肌肉减少症”，采用 MeSH 术语和条目组合的形式来查找文献。两名评审员将独立评估每个标题和摘要。所有记录 KOA 患者 SA 患病率和/或相关因素的观察性研究都将被纳入。将使用 Stata 18.0 软件对 SA 的患病率进行单组荟萃分析。使用随机效应和质量效应模型计算具有 95%CI 的汇总患病率。使用随机效应 Meta 分析计算汇总相对危险度。主要分析结果将包括根据诊断标准、KOA 病程、疾病状态（例如膝关节疼痛、疾病持续时间）、体力活动、诊断标准和不同地理背景，KOA 患者中 SA 患病率的差异。次要结果可能分析性别和年龄等亚组，并且还将使用 Meta 回归分析来综合影响 SA 的因素。还将评估研究之间的敏感性分析和异质性以及发表偏倚的证据。
本综述将根据现有证据总结 KOA 患者中 SA 的患病率和影响因素。预计结果将确定知识差距和进一步研究的领域。该综述将提交给特定主题的期刊发表，并分发给专业网络。不包括个体患者数据，因此不需要伦理批准。
PROSPERO 注册号：CRD42023490539。
