• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

了解 TNFR2 信号在乳腺癌肿瘤微环境中的作用。

Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer.

机构信息

Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu , Kelantan, 16150, Malaysia.

Department of Biology, Faculty of Education, Omdurman Islamic University, P.O. Box 382, Omdurman, Sudan.

出版信息

J Exp Clin Cancer Res. 2024 Nov 28;43(1):312. doi: 10.1186/s13046-024-03218-1.

DOI:10.1186/s13046-024-03218-1
PMID:39609700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11603874/
Abstract

Breast cancer (BC) is the most frequently diagnosed malignancy among women. It is characterized by a high level of heterogeneity that emerges from the interaction of several cellular and soluble components in the tumor microenvironment (TME), such as cytokines, tumor cells and tumor-associated immune cells. Tumor necrosis factor (TNF) receptor 2 (TNFR2) appears to play a significant role in microenvironmental regulation, tumor progression, immune evasion, drug resistance, and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood. This review provides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-κB, MAPK, and PI3K/Akt pathways). We discuss potential therapeutic strategies targeting TNFR2, with the aim of enhancing the antitumor immune response to BC. This review provides insights into role of TNFR2 as a major immune checkpoint for the future treatment of patients with BC.

摘要

乳腺癌（BC）是女性中最常见的恶性肿瘤。它的特点是高度异质性，这种异质性源于肿瘤微环境（TME）中几种细胞和可溶性成分的相互作用，如细胞因子、肿瘤细胞和肿瘤相关免疫细胞。肿瘤坏死因子（TNF）受体 2（TNFR2）似乎在多种癌症（包括 BC）的微环境调节、肿瘤进展、免疫逃逸、耐药性和转移中发挥重要作用。然而，TNFR2 在 BC 生物学中的意义尚不完全清楚。这篇综述概述了 TNFR2 的生物学特性，详细描述了其激活及其与 TME 中重要信号通路（如 NF-κB、MAPK 和 PI3K/Akt 通路）的相互作用。我们讨论了针对 TNFR2 的潜在治疗策略，旨在增强对 BC 的抗肿瘤免疫反应。这篇综述深入了解了 TNFR2 作为主要免疫检查点在未来治疗 BC 患者中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/d599fde8cac2/13046_2024_3218_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/2164c1aa29d7/13046_2024_3218_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/1c86d05c1f26/13046_2024_3218_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/be92bfd4b247/13046_2024_3218_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/0dbecae4a406/13046_2024_3218_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/39cad5f8a692/13046_2024_3218_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/f5c14f82e546/13046_2024_3218_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/d7257105ff46/13046_2024_3218_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/6e2d03ffb69b/13046_2024_3218_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/1e14b7419048/13046_2024_3218_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/2514e6d91bd6/13046_2024_3218_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/23fa0a6facd9/13046_2024_3218_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/d599fde8cac2/13046_2024_3218_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/2164c1aa29d7/13046_2024_3218_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/1c86d05c1f26/13046_2024_3218_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/be92bfd4b247/13046_2024_3218_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/0dbecae4a406/13046_2024_3218_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/39cad5f8a692/13046_2024_3218_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/f5c14f82e546/13046_2024_3218_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/d7257105ff46/13046_2024_3218_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/6e2d03ffb69b/13046_2024_3218_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/1e14b7419048/13046_2024_3218_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/2514e6d91bd6/13046_2024_3218_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/23fa0a6facd9/13046_2024_3218_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5632/11603874/d599fde8cac2/13046_2024_3218_Fig12_HTML.jpg

相似文献

1
Understanding the role of TNFR2 signaling in the tumor microenvironment of breast cancer.了解 TNFR2 信号在乳腺癌肿瘤微环境中的作用。
J Exp Clin Cancer Res. 2024 Nov 28;43(1):312. doi: 10.1186/s13046-024-03218-1.
2
The Roles of TNFR2 Signaling in Cancer Cells and the Tumor Microenvironment and the Potency of TNFR2 Targeted Therapy.TNFR2 信号在癌细胞和肿瘤微环境中的作用及 TNFR2 靶向治疗的效力。
Cells. 2022 Jun 17;11(12):1952. doi: 10.3390/cells11121952.
3
Continuous TNF-α exposure in mammary epithelial cells promotes cancer phenotype acquisition via EGFR/TNFR2 activation.持续的 TNF-α 暴露可通过 EGFR/TNFR2 激活促进乳腺上皮细胞获得癌症表型。
Arch Pharm Res. 2024 May;47(5):465-480. doi: 10.1007/s12272-024-01497-y. Epub 2024 May 11.
4
Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling.肿瘤坏死因子受体 2 介导的 JNK 信号通路需要内化和 AIP1 相关联。
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2271-9. doi: 10.1161/ATVBAHA.112.253666. Epub 2012 Jun 28.
5
TNFR2 expression predicts the responses to immune checkpoint inhibitor treatments.TNFR2 表达预测免疫检查点抑制剂治疗的反应。
Front Immunol. 2023 Feb 14;14:1097090. doi: 10.3389/fimmu.2023.1097090. eCollection 2023.
6
Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells.阻断 TNF-α/TNFR2 信号通路可抑制结直肠癌，并通过减少 CCR8+T 调节细胞来增强抗 PD-1 免疫治疗的疗效。
J Mol Cell Biol. 2024 Nov 25;16(6). doi: 10.1093/jmcb/mjad067.
7
Decoding tumor microenvironment: EMT modulation in breast cancer metastasis and therapeutic resistance, and implications of novel immune checkpoint blockers.解码肿瘤微环境：乳腺癌转移和治疗耐药中的上皮-间质转化调控以及新型免疫检查点阻断剂的影响
Biomed Pharmacother. 2024 Dec;181:117714. doi: 10.1016/j.biopha.2024.117714. Epub 2024 Nov 29.
8
TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.肿瘤坏死因子受体 2（TNFR2）增加配体诱导的丝裂原活化蛋白激酶（p38 MAPK）和核因子-κB（NF-κB）通路的激活敏感性，并在巨噬细胞中信号转导 TRAF2 蛋白降解。
Cell Signal. 2014 Apr;26(4):683-90. doi: 10.1016/j.cellsig.2013.12.009. Epub 2013 Dec 27.
9
TNFR2: A Novel Target for Cancer Immunotherapy.TNFR2：癌症免疫治疗的新靶点。
Trends Mol Med. 2017 Nov;23(11):1037-1046. doi: 10.1016/j.molmed.2017.09.007. Epub 2017 Oct 12.
10
In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors.通过溶瘤腺病毒对肿瘤坏死因子-肿瘤坏死因子受体2轴进行原位阻断可提高实体瘤的抗肿瘤疗效。
Mol Ther. 2025 Feb 5;33(2):670-687. doi: 10.1016/j.ymthe.2024.12.011. Epub 2024 Dec 16.

本文引用的文献

1
Targeting TNFR2 for cancer immunotherapy: recent advances and future directions.针对肿瘤免疫疗法的 TNFR2 靶点：最新进展和未来方向。
J Transl Med. 2024 Sep 2;22(1):812. doi: 10.1186/s12967-024-05620-x.
2
The present and future of bispecific antibodies for cancer therapy.双特异性抗体在癌症治疗中的现在和未来。
Nat Rev Drug Discov. 2024 Apr;23(4):301-319. doi: 10.1038/s41573-024-00896-6. Epub 2024 Mar 6.
3
Beyond the barrier: the immune-inspired pathways of tumor extravasation.超越障碍：肿瘤外渗的免疫启发途径。
Cell Commun Signal. 2024 Feb 8;22(1):104. doi: 10.1186/s12964-023-01429-1.
4
Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ.缺氧诱导因子抑制剂通过 IKKϵ 的羟化作用负调控抗病毒先天免疫。
Cell Rep. 2024 Jan 23;43(1):113606. doi: 10.1016/j.celrep.2023.113606. Epub 2023 Dec 20.
5
A novel single domain bispecific antibody targeting VEGF and TNF-α ameliorates rheumatoid arthritis.一种新型靶向 VEGF 和 TNF-α 的单域双特异性抗体可改善类风湿关节炎。
Int Immunopharmacol. 2024 Jan 5;126:111240. doi: 10.1016/j.intimp.2023.111240. Epub 2023 Nov 22.
6
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn.嵌合抗原受体 T 细胞疗法治疗实体瘤患者：需要汲取和摒弃的关键经验。
Nat Rev Clin Oncol. 2024 Jan;21(1):47-66. doi: 10.1038/s41571-023-00832-4. Epub 2023 Oct 30.
7
CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer.CXCR4 修饰的 CAR-T 细胞通过 STAT3/NF-κB/SDF-1α 轴抑制 MDSCs 的募集，以增强对胰腺癌的疗效。
Mol Ther. 2023 Nov 1;31(11):3193-3209. doi: 10.1016/j.ymthe.2023.09.010. Epub 2023 Sep 20.
8
The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis.TNFα/TNFR2 轴通过促进有氧糖酵解来介导自然杀伤细胞增殖。
Cell Mol Immunol. 2023 Oct;20(10):1140-1155. doi: 10.1038/s41423-023-01071-4. Epub 2023 Aug 9.
9
TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond.肿瘤坏死因子（TNF）及其受体作为治疗风湿性疾病及其他疾病的靶点。
Nat Rev Rheumatol. 2023 Sep;19(9):576-591. doi: 10.1038/s41584-023-01002-7. Epub 2023 Aug 4.
10
CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8 T cell antitumor immunity.CXCR3 在调节性 T 细胞中的表达驱动其与肿瘤中 I 型树突状细胞的相互作用，从而限制 CD8 T 细胞的抗肿瘤免疫。
Immunity. 2023 Jul 11;56(7):1613-1630.e5. doi: 10.1016/j.immuni.2023.06.003. Epub 2023 Jun 30.