Philipp M, Maier W
Pharmacopsychiatry. 1986 Jan;19(1):43-7. doi: 10.1055/s-2007-1017150.
Operational diagnoses of endogenous depression have gained special importance for psychopharmacological research. The high reliability of operationally defined diagnoses is a prerequisite for sampling comparable patient group. The simultaneous application of competing categorical diagnostic system ("polydiagnosis") allows us to determine whether differences in research findings are due to differences in patient samplings. Furthermore, a dimensional classification of patients by means of a newly developed polydiagnostic scale (so called OPD scale) allows us to compare the diagnostic homogeneity of patient groups diagnosed as endogenous depression cases and to select extreme groups with high diagnostic homogeneity for comparing the distribution of variables under research in patients with endogenous and nonendogenous depression.
内源性抑郁症的操作性诊断在精神药理学研究中具有特殊的重要性。操作性定义诊断的高可靠性是抽取可比患者组的前提条件。同时应用相互竞争的分类诊断系统（“多重诊断”）使我们能够确定研究结果的差异是否源于患者样本的差异。此外，通过新开发的多重诊断量表（即所谓的OPD量表）对患者进行维度分类，使我们能够比较诊断为内源性抑郁症病例的患者组的诊断同质性，并选择具有高诊断同质性的极端组，以比较内源性和非内源性抑郁症患者研究中变量的分布。
