Movement and Cognition Laboratory, University of Haifa, Eshkol Building Room 910, Haifa, Israel.
Resonance Therapeutics Laboratory, Department of Neurology, Universidad de Ciencias Médicas de La Habana, Havana, Cuba.
J Med Case Rep. 2024 Nov 28;18(1):574. doi: 10.1186/s13256-024-04888-3.
In this pilot study a binaural pulse modulator was tested to see if it leads to a change in self-reported measures of distress. This binaural pulse modulator produces two frequencies that combine to create a binaural pulse to stimulate the nervous system through a differential auditory tone presentation and the response of the user can be adjusted to the appropriate target tone for effective treatment use. Each individual calibrated the binaural pulse to increase the level of emotion experienced while imagining an experience with a similar emotional valence or while engaged in a cognitive function while also listening to the sound. "Treatment" is based on the client's control of the binaural pulses to achieve the desired state. Training focuses on specific aspects of their psychological difficulties while listening to an auditory tone, turning a knob until the sound becomes uncomfortable. Finally, another knob is turned to cancel out the uncomfortable noise which appears to be associated with a reduction in distress.
Four adult Hispanic participants (three females and one male) were studied with self-reported measures of distress (generalized anxiety disorder 7, Coronavirus Disease Stress Scale, posttraumatic stress disorder checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and Beck depression scale II) were completed at screening, before treatment, after treatment, 4-weeks post-treatment, and 12-weeks post-treatment. Quantitative electroencephalogram and functional magnetic resonance imaging were also performed before and after treatment.
Preliminary findings indicated that at the end of treatment with binaural pulse modulator there were reported reductions in self-reported levels of distress. Quantitative electroencephalogram as well as functional magnetic resonance imaging changes in brain state were also noted when comparing pre- to post-treatment.
binaural pulse modulator use appears to result in temporary changes in self-reported levels of distress during treatment. Limitations of the study are reviewed and directions for further research are offered.
在这项初步研究中，测试了双耳脉冲调制器，以观察其是否会导致自我报告的痛苦程度发生变化。这种双耳脉冲调制器产生两个频率，通过差频听觉呈现相结合，刺激神经系统，用户的反应可以调整到适当的目标音调，以实现有效的治疗效果。每个人都可以校准双耳脉冲，以增加在想象具有相似情感效价的体验或在进行认知功能的同时聆听声音时所经历的情绪水平。“治疗”基于客户对双耳脉冲的控制，以达到预期的状态。训练侧重于在聆听听觉音调时解决他们心理困难的具体方面，直到声音变得不适为止，转动旋钮。最后，再转动另一个旋钮以消除不适感，这种不适感似乎与痛苦程度的降低有关。
研究了 4 名成年西班牙裔参与者（3 名女性和 1 名男性），他们报告了痛苦程度（广泛性焦虑症 7 项、冠状病毒疾病应激量表、精神疾病诊断和统计手册第五版创伤后应激障碍检查表和贝克抑郁量表 II），在筛选时、治疗前、治疗后、治疗后 4 周和治疗后 12 周完成。还在治疗前后进行了定量脑电图和功能磁共振成像。
初步研究结果表明，在双耳脉冲调制器治疗结束时，报告的痛苦程度有所降低。还注意到定量脑电图和大脑状态的功能磁共振成像变化，在治疗前后进行了比较。
双耳脉冲调制器的使用似乎会导致治疗期间自我报告的痛苦程度暂时变化。审查了研究的局限性，并提出了进一步研究的方向。
