Shi Ying, Han Xin, Zou Siyi, Liu Guozhen
Integrated Devices and Intelligent Diagnosis (ID2) Laboratory, CUHK(SZ)-Boyalife Joint Laboratory of Regenerative Medicine Engineering, Biomedical Engineering Programme, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.
ACS Nano. 2024 Dec 10;18(49):33276-33292. doi: 10.1021/acsnano.4c13330. Epub 2024 Nov 28.
Organoids are three-dimensional models of microscopic organisms created through the self-organization of various types of stem cells. They are widely unitized in personalized medicine due to their capacity to replicate the structure and functionality of native organs. Meanwhile, nanotechnology has been integrated into diagnostic and therapeutic tools to manage an array of medical conditions, given its unique characteristics of nanoscale. Nanomaterials have demonstrated potential in developing innovative and effective organoids. With a focus on studying the interaction of nanomaterials and organoid technology in personalized medicine, this Review examines the role of nanomaterials in regulating the fate of stem cells to construct different types of organoids. It also explores the potential of nanotechnology to create 3D microenvironments for organoids. Finally, perspectives and challenges of applying nanotechnology for organoids development toward the translation of personalized medicine are discussed.
类器官是通过各种类型干细胞的自我组织创建的微观生物体的三维模型。由于它们能够复制天然器官的结构和功能，因此在个性化医疗中得到广泛应用。同时，鉴于纳米技术的独特纳米尺度特性，它已被整合到诊断和治疗工具中，用于管理一系列医疗状况。纳米材料在开发创新且有效的类器官方面已显示出潜力。本综述聚焦于研究纳米材料与类器官技术在个性化医疗中的相互作用，探讨了纳米材料在调控干细胞命运以构建不同类型类器官中的作用。还探讨了纳米技术为类器官创造三维微环境的潜力。最后，讨论了将纳米技术应用于类器官开发以推动个性化医疗转化的前景和挑战。
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