Ahdieh H B, Brown T J, Wade G N, Blaustein J D
Physiol Behav. 1986;36(2):211-5. doi: 10.1016/0031-9384(86)90005-3.
In order to determine if the enhancement of sexual behavior in hysterectomized rats is associated with an increased level of hypothalamic nuclear progestin receptors, ovariectomized (OVX) and ovariectomized-hysterectomized (OVHX) rats were injected with 2 micrograms estradiol benzoate. Twenty-four hr later, animals were injected with 0.5 mg progesterone and were tested for sexual receptivity every 4 hr. Hysterectomy had an overall facilitatory effect on lordosis and increased the duration of the period of sexual receptivity by about 4 hr. In a second experiment, similarly-treated animals were killed 4, 8, or 12 hr after progesterone injection, and hypothalamic nuclear progestin receptor levels were measured. In contrast to what has been reported for guinea pigs, nuclear progestin receptor levels decreased to baseline 8-12 hr before the termination of sexual receptivity. Nuclear progestin receptor concentrations were higher in OVHX rats than in OVX rats at 4 hr after progesterone injection, and there was a trend toward higher receptor concentrations in OVHX rats at 8 hr. These results demonstrate that hysterectomy-induced facilitation of sexual receptivity is associated with an increased level of hypothalamic nuclear progestin receptors. Furthermore, they suggest a fundamental difference in the regulation of nuclear progestin receptor retention between rats and guinea pigs.
为了确定子宫切除大鼠性行为的增强是否与下丘脑核孕激素受体水平的升高有关，对去卵巢（OVX）和去卵巢-子宫切除（OVHX）大鼠注射2微克苯甲酸雌二醇。24小时后，给动物注射0.5毫克孕酮，并每4小时测试一次性接受能力。子宫切除术对脊柱前凸有总体促进作用，并使性接受期的持续时间增加了约4小时。在第二个实验中，对同样处理的动物在注射孕酮后4、8或12小时处死，并测量下丘脑核孕激素受体水平。与豚鼠的报道相反，核孕激素受体水平在性接受期结束前8 - 12小时降至基线。注射孕酮后4小时，OVHX大鼠的核孕激素受体浓度高于OVX大鼠，且在8小时时OVHX大鼠的受体浓度有升高趋势。这些结果表明，子宫切除引起的性接受能力增强与下丘脑核孕激素受体水平升高有关。此外，它们提示大鼠和豚鼠在核孕激素受体保留的调节方面存在根本差异。
