Ahdieh H B, Siegel H I, Wade G N
Horm Behav. 1985 Sep;19(3):292-303. doi: 10.1016/0018-506x(85)90028-5.
These experiments examined the effects of hysterectomy on heat duration and on the reinduction of estrous behavior by progesterone (P) following the termination of spontaneous heat in 4-day cycling rats. Hysterectomy did not affect the onset of estrus but prolonged heat duration. The average duration of sexual receptivity for hysterectomized (H) and sham-hysterectomized (SH) rats was 18.2 and 13.0 hr, respectively. Furthermore, H animals injected with either 0.5 mg P within 2 hr, or 4.0 mg P 24 hr following the termination of natural estrus showed significantly higher lordosis and solicitation responses than SH rats similarly treated. These behavioral findings were correlated with the level of hypothalamic progestin receptors. That is, H animals had a significantly higher concentration of progestin receptors than SH rats immediately following the termination of spontaneous heat and also 24 hr later. Both in estrous-cycling rats and in gonadectomized animals treated with estradiol benzoate (EB), hysterectomy resulted in higher serum estradiol (E2) levels. The results of these experiments suggest that prolongation of the period of sexual receptivity and the facilitated behavioral responses to P following the cessation of estrus in hysterectomized animals may be due to a lowered clearance rate of circulating estradiol which presumably enhances the estrogen conditioning of the neural substrates.
这些实验研究了子宫切除术对4日周期大鼠自发性发情期结束后发情持续时间以及孕酮（P）诱导发情行为再出现的影响。子宫切除术不影响发情期的开始，但延长了发情持续时间。子宫切除（H）组和假手术切除（SH）组大鼠的平均性接受期分别为18.2小时和13.0小时。此外，在自然发情期结束后2小时内注射0.5毫克P或24小时后注射4.0毫克P的H组动物，与接受类似处理的SH组大鼠相比，表现出明显更高的脊柱前凸和求偶反应。这些行为学发现与下丘脑孕激素受体水平相关。也就是说，在自发性发情期结束后立即以及24小时后，H组动物的孕激素受体浓度显著高于SH组大鼠。在发情周期的大鼠以及用苯甲酸雌二醇（EB）处理的性腺切除动物中，子宫切除术都会导致血清雌二醇（E2）水平升高。这些实验结果表明，子宫切除动物发情期结束后性接受期的延长以及对P的行为反应增强，可能是由于循环雌二醇清除率降低，这可能增强了神经基质的雌激素调节作用。
