Gamallo A, Villanua A, Trancho G, Fraile A
Physiol Behav. 1986;36(2):217-21. doi: 10.1016/0031-9384(86)90006-5.
Socially reared male control rats (Co) were compared with crowded reared rats (Cr) and isolated reared rats (I). We assayed the adaptation to moderate stress (activity and defecation rate in open-field test) and to intensive stress sensitivity to restraint ulcer), so as the basal adrenal activity measuring basal values of corticosterone (R.I.A.) and fresh weight of adrenal and thymus glands. Results show a great lack of adaptation to moderate and intensive stress in Cr and I reared rats which leads to a decrease of activity variables, an increase of defecation rates and a high sensitivity to restraint ulcers. The effect of crowding conditions show higher values than isolation. We also found, in isolated and crowded reared rats, an increase in the adrenal function with great values for the basal secretion of corticosterone and atrophy of the thymus gland, besides which, crowded reared animals showed adrenal hypertrophy.
将社会饲养的雄性对照大鼠（Co）与拥挤饲养的大鼠（Cr）和单独饲养的大鼠（I）进行比较。我们测定了对中度应激（旷场试验中的活动和排便率）和对强烈应激（束缚性溃疡敏感性）的适应性，以及基础肾上腺活动，测量了皮质酮的基础值（放射免疫分析）和肾上腺及胸腺的鲜重。结果表明，Cr组和I组饲养的大鼠对中度和强烈应激的适应性严重不足，这导致活动变量减少、排便率增加以及对束缚性溃疡的高敏感性。拥挤条件的影响显示出比隔离更高的值。我们还发现，在单独饲养和拥挤饲养的大鼠中，肾上腺功能增强，皮质酮基础分泌值很高，胸腺萎缩，此外，拥挤饲养的动物出现肾上腺肥大。
