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疫苗犹豫对患有慢性病的老年人群中肺炎球菌疫苗拒绝接种的影响。

Vaccine Hesitancy Affecting Pneumococcal Vaccine Refusal in Older Adults with Morbidities.

机构信息

Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Global Health and Chronic Conditions Research Group, Chiang Mai University, Chiang Mai, Thailand.

出版信息

J Prim Care Community Health. 2024 Jan-Dec;15:21501319241303568. doi: 10.1177/21501319241303568.

DOI:10.1177/21501319241303568
PMID:39610088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11605742/
Abstract

INTRODUCTION

Pneumonia is a leading cause of mortality worldwide, with Streptococcus pneumoniae being the most common cause. Older adults are particularly at risk. However, vaccination rates in Thailand remain low.

OBJECTIVE

This study aims to examine the prevalence of vaccine refusal and its association with factors outlined in the 5C model (Confidence, Complacency, Constraints, Calculation, and Collective Responsibility) among older patients with morbidities.

SETTING

Study was conducted at outpatient clinic of the Department of Family Medicine, Chiang Mai University.

METHODS

An observational cross-sectional study. The data was collected via a self-administered questionnaire including demographic data, questionnaire in 5C model, and intention to received pneumococcal vaccine. Comparison of characteristic between vaccine refuser and non-refuser was performed by using Chi-square or a -test. To explore the association between factors in 5C model and vaccine refusal, multiple logistic regression was performed with an adjustment for confounders.

RESULTS

From a total of 150 participants, the mean age was 69.8 ± 5.6 years old. Most of the patients were female (60.7%). The study found that 18% of the participants refused the pneumococcal vaccine. After adjusted for the confounders, the lower collective responsibility and confidence were significantly associated with vaccine refusal (Odds ratio 0.22 (95% confidence interval [CI] 0.06-0.74,  = .015) and Odds ratio 0.43 (95% CI 0.20-0.89,  = .024), respectively.

CONCLUSION

Strategies to enhance confidence and address complacency about vaccines are essential for improving pneumococcal vaccination coverage. This insight can be used as a guideline and policies can be formulated which are aimed at reducing pneumococcal vaccine refusal in the older adults by enhancing communication about the benefits, efficacy, and risks of vaccines.

摘要

引言

肺炎是全球范围内导致死亡的主要原因,其中肺炎链球菌是最常见的病因。老年人的风险尤其高。然而,泰国的疫苗接种率仍然很低。

目的

本研究旨在检查患有慢性病的老年患者中疫苗拒绝接种及其与 5C 模型(信心、自满、约束、计算和集体责任)中列出的因素的相关性。

设置

研究在清迈大学家庭医学系的门诊进行。

方法

采用观察性横断面研究。通过自填式问卷收集数据,包括人口统计学数据、5C 模型问卷和接种肺炎球菌疫苗的意愿。使用卡方检验或 t 检验比较疫苗拒绝者和非拒绝者的特征。为了探索 5C 模型中的因素与疫苗拒绝之间的关联,采用多元逻辑回归分析,并对混杂因素进行调整。

结果

在总共 150 名参与者中,平均年龄为 69.8±5.6 岁。大多数患者为女性(60.7%)。研究发现,18%的参与者拒绝接种肺炎球菌疫苗。在调整混杂因素后,较低的集体责任感和信心与疫苗拒绝显著相关(优势比 0.22(95%置信区间 [CI] 0.06-0.74,P=0.015)和优势比 0.43(95% CI 0.20-0.89,P=0.024))。

结论

增强对疫苗的信心和解决对疫苗的自满情绪的策略对于提高肺炎球菌疫苗接种覆盖率至关重要。这一发现可以作为一个指导方针,并制定政策,旨在通过加强关于疫苗的益处、疗效和风险的沟通,减少老年人对肺炎球菌疫苗的拒绝。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/bd0e886a682b/10.1177_21501319241303568-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/896666e6ead5/10.1177_21501319241303568-img2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/21362c9bd3d8/10.1177_21501319241303568-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/bd0e886a682b/10.1177_21501319241303568-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/896666e6ead5/10.1177_21501319241303568-img2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/21362c9bd3d8/10.1177_21501319241303568-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/321c/11605742/bd0e886a682b/10.1177_21501319241303568-fig2.jpg

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本文引用的文献

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COVID-19 vaccination in pregnancy: the impact of multimorbidity and smoking status on vaccine hesitancy, a cohort study of 25,111 women in Wales, UK.COVID-19 孕期疫苗接种:在威尔士 UK 对 25111 名女性的队列研究中,合并症和吸烟状况对疫苗犹豫的影响。
BMC Infect Dis. 2023 Sep 11;23(1):594. doi: 10.1186/s12879-023-08555-8.
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Muslim parents' beliefs and factors influencing complete immunization of children aged 0-5 years in a Thai rural community: a qualitative study.
穆斯林父母的信仰及影响泰国农村 0-5 岁儿童完全免疫的因素:一项定性研究。
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Hospitalisation outcomes in pneumococcal-vaccinated -unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study.肺炎球菌疫苗接种与未接种的慢性阻塞性肺疾病急性加重患者的住院结局:HOPE COPD研究结果
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