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A TRIM21-based method for targeted protein degradation.

作者信息

Hu Weikang, Qiu Xiang, Yang Yun, Wu Yaoyao, Wang Chengcheng, Hu Ronggui, Li Chuanyin

机构信息

Medical College of Guizhou University, Guiyang 550025, China.

State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.

出版信息

Acta Biochim Biophys Sin (Shanghai). 2024 Nov 27;57(4):667-670. doi: 10.3724/abbs.2024179.

DOI:10.3724/abbs.2024179
PMID:39610276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040746/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8681/12040746/c45fd7edb578/t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8681/12040746/a84daaab88dc/t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8681/12040746/c45fd7edb578/t2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8681/12040746/a84daaab88dc/t1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8681/12040746/c45fd7edb578/t2.jpg

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Mol Cell. 2024 Apr 18;84(8):1585-1600.e7. doi: 10.1016/j.molcel.2024.02.019. Epub 2024 Mar 12.
2
Structure of the p53 degradation complex from HPV16.HPV16 型 p53 降解复合物的结构。
Nat Commun. 2024 Feb 28;15(1):1842. doi: 10.1038/s41467-024-45920-w.
3
The ubiquitin codes in cellular stress responses.泛素码在细胞应激反应中的作用。
Protein Cell. 2024 Feb 29;15(3):157-190. doi: 10.1093/procel/pwad045.
4
USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer.USP14 通过去泛素化 CDK1 调节乳腺癌细胞周期进程。
Acta Biochim Biophys Sin (Shanghai). 2022 Nov 25;54(11):1610-1618. doi: 10.3724/abbs.2022160.
5
Targeted protein degradation: mechanisms, strategies and application.靶向蛋白降解：机制、策略与应用。
Signal Transduct Target Ther. 2022 Apr 4;7(1):113. doi: 10.1038/s41392-022-00966-4.
6
Targeted Intracellular Delivery of Antibodies: The State of the Art.抗体的靶向细胞内递送：现状
Front Pharmacol. 2018 Oct 24;9:1208. doi: 10.3389/fphar.2018.01208. eCollection 2018.
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Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.细胞内抗体信号受 Fc 受体 TRIM21 的磷酸化调节。
Elife. 2018 Apr 18;7:e32660. doi: 10.7554/eLife.32660.
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A Method for the Acute and Rapid Degradation of Endogenous Proteins.一种内源性蛋白质急性快速降解的方法。
Cell. 2017 Dec 14;171(7):1692-1706.e18. doi: 10.1016/j.cell.2017.10.033. Epub 2017 Nov 16.
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Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders.UBE3A 过量会损害自闭症谱系障碍中的视黄酸信号和突触可塑性。
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10
Ubiquitin modifications.泛素修饰
Cell Res. 2016 Apr;26(4):399-422. doi: 10.1038/cr.2016.39. Epub 2016 Mar 25.