Hasani Motahareh, Khazdouz Maryam, Sobhani Sahar, Mardi Parham, Riahi Shirin, Agh Fahimeh, Mahdavi-Gorabi Armita, Mohammadipournami Sahar, Gomnam Fatemeh, Qorbani Mostafa
Department of Nutrition, School of Public Health, Golestan University of Medical Sciences, Gorgan, Iran.
Ali-Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.
J Diabetes Metab Disord. 2024 Nov 4;23(2):1719-1752. doi: 10.1007/s40200-024-01500-9. eCollection 2024 Dec.
The literature has reported heavy metals might alter the physiological and biochemical functions of body organs and cause several health problems. So, the present systematic review and meta-analysis aimed to investigate the association of blood levels of essential or non-essential metals with metabolic syndrome (MetS).
In this systematic review, some international databases including PubMed, Embase, Scopus, and Web of Science were searched up to February 2024. All observational studies which assessed the association of three heavy metals (cadmium, mercury, lead) and bio-elements (chromium, iron, manganese, and magnesium, copper) with the risk of MetS were included. There was no limitation in the time of publication and language. A random-effects meta-analysis was performed to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by meta-regression analysis.
Totally, 29 studies were eligible for meta-analysis. Our results showed that increased level of cadmium (pooled OR: 1.24, 95% CI: 1.05, 1.46) and mercury (pooled OR: 1.22, 95% CI: 1.08, 1.38) significantly increased the risk of MetS. In contrast, increased level of chromium significantly reduced the risk of developing MetS (pooled OR: 0.68, 95% CI: 0.56, 0.83). Moreover, association between lead, iron, copper, magnesium, and manganese with MetS was not statistically significant (P > 0.05). However, elevated lead levels in men increased the odds of MetS.
Our results show a significant association between blood levels of some heavy metals, including cadmium, mercury, and lead, with increased odds of MetS. On the other hand, chromium as a biometal decreased the odds of MetS.
The online version contains supplementary material available at 10.1007/s40200-024-01500-9.
文献报道重金属可能改变身体器官的生理和生化功能，并引发多种健康问题。因此，本系统评价和荟萃分析旨在研究必需或非必需金属的血液水平与代谢综合征（MetS）之间的关联。
在本系统评价中，检索了截至2024年2月的一些国际数据库，包括PubMed、Embase、Scopus和Web of Science。纳入所有评估三种重金属（镉、汞、铅）和生物元素（铬、铁、锰、镁、铜）与MetS风险之间关联的观察性研究。对发表时间和语言没有限制。进行随机效应荟萃分析以估计合并效应量。通过荟萃回归分析探索异质性的可能来源。
共有29项研究符合荟萃分析的条件。我们的结果表明，镉水平升高（合并比值比：1.24，95%置信区间：1.05，1.46）和汞水平升高（合并比值比：1.22，95%置信区间：1.08，1.38）显著增加了MetS的风险。相比之下，铬水平升高显著降低了发生MetS的风险（合并比值比：0.68，95%置信区间：0.56，0.83）。此外，铅、铁、铜、镁和锰与MetS之间的关联无统计学意义（P＞0.05）。然而，男性铅水平升高会增加患MetS的几率。
我们的结果表明，包括镉、汞和铅在内的一些重金属的血液水平与MetS几率增加之间存在显著关联。另一方面，铬作为一种生物金属降低了MetS的几率。
在线版本包含可在10.1007/s40200-024-01500-9获取的补充材料。
