Zhao Chengcheng, Li Youhao, Wang Hui, Solomon Ahamba Ifeanyi, Wang Shuhui, Dong Xianggui, Song Bing, Ren Zhanjun
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Microbiol Spectr. 2025 Jan 7;13(1):e0006724. doi: 10.1128/spectrum.00067-24. Epub 2024 Nov 29.
Early weaning is frequently accompanied by a significant increase in diarrhea and mortality rates, which reduces rabbits' performance. Although antibiotics can reduce pathogenic bacteria, they also harm beneficial microorganisms and disrupt the normal intestinal microbiota balance. In order to find non-residue and non-toxic alternatives to antibiotics to ensure the safety of animal products, we conducted a study on the effect of compound microecological preparations supplementation on lactating female rabbits and their offspring. A total of 60 female rabbits were randomly assigned to four groups: CON, supplemented with probiotics at 3, 6, and 9 g/female rabbit/day from day 24 of gestation until weaning. We observed that probiotics supplementation significantly enhanced production performance ( < 0.05), immune and antioxidant function ( < 0.05), as well as intestinal flora composition in lactating rabbits and their offspring. Notably, compared with the control group, the experimental group exhibited a 19.23%, 44.22%, and 24.57% increase in milk yield ( = 0.002). Regarding rabbit growth performance, the average body weight of young rabbits in the experimental group showed a significant increase of 3.59%, 10.22%, and 6.74% at day 35 ( = 0.022), whereas the average daily gain (ADG) of rabbits aged between 21 and 35 days was significantly elevated by 4.94%, 17.06%, and 6.28% in the experimental group ( < 0.001). In conclusion, probiotics supplementation can significantly enhance lactation performance, promote growth and disease resistance in rabbits, as well as improve intestinal health when administered at a dosage of 6 g/day. Moreover, the limited sample size in this study may hinder the detection of subtle effects, and augmenting the sample size will bolster the reliability of the study findings.
The intestinal environment of rabbits is fragile and susceptible to environmental influences, leading to inflammatory intestinal diseases. Adding antibiotics to rabbit feed can achieve the effect of preventing and treating inflammation, which can also lead to the imbalance of the gut microbiota and residual antibiotics in agricultural products. Composite probiotics are live microbial feed additives composed of various ratios of probiotics and have become the most promising alternative to antibiotics due to their residue-free and non-toxic properties. The aim of this study was to investigate the impact of compound probiotics on lactating female rabbits and their offspring. Our findings highlight the potential of compound microecological preparations as an effective strategy for enhancing lactation performance, immune function, and antioxidant capacity in rabbits. The supplementation of probiotics through rabbit milk offers a promising approach to optimize the growth and health outcomes of newborn rabbits.
早期断奶常常伴随着腹泻率和死亡率的显著上升，这会降低兔子的生产性能。尽管抗生素可以减少病原菌，但它们也会损害有益微生物并破坏正常的肠道微生物群平衡。为了找到抗生素的无残留、无毒替代品以确保动物产品的安全，我们开展了一项关于补充复合微生态制剂对泌乳母兔及其后代影响的研究。总共60只母兔被随机分为四组：对照组（CON），从妊娠第24天到断奶，每只母兔每天补充3克、6克和9克益生菌。我们观察到，补充益生菌显著提高了泌乳母兔及其后代的生产性能（P<0.05）、免疫和抗氧化功能（P<0.05）以及肠道菌群组成。值得注意的是，与对照组相比，实验组的产奶量分别提高了19.23%、44.22%和24.57%（P = 0.002）。关于兔子的生长性能，实验组幼兔在35日龄时的平均体重显著增加了3.59%、10.22%和6.74%（P = 0.022），而在21至35日龄的兔子中，实验组的平均日增重（ADG）分别显著提高了4.94%、17.06%和6.28%（P<0.001）。总之，以每天6克的剂量补充益生菌可以显著提高母兔的泌乳性能，促进兔子的生长和抗病能力，并改善肠道健康。此外，本研究中有限的样本量可能会妨碍对细微效应的检测，增加样本量将提高研究结果的可靠性。
兔子的肠道环境脆弱，容易受到环境影响，从而引发肠道炎症性疾病。在兔子饲料中添加抗生素可以达到预防和治疗炎症的效果，但这也会导致肠道微生物群失衡以及农产品中抗生素残留。复合益生菌是由不同比例的益生菌组成的活微生物饲料添加剂，由于其无残留、无毒的特性，已成为抗生素最有前景的替代品。本研究的目的是调查复合益生菌对泌乳母兔及其后代的影响。我们的研究结果突出了复合微生态制剂作为提高兔子泌乳性能、免疫功能和抗氧化能力的有效策略的潜力。通过兔奶补充益生菌为优化新生兔的生长和健康状况提供了一种有前景的方法。
