Si Yu, Wang Lei, Wu Hao, Yan Shoucai, Wang Yang, Qian Xiao, Liu Ziang, Akkaya Engin U
State Key Laboratory of Fine Chemicals, and Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Chem Asian J. 2025 Jan 17;20(2):e202401051. doi: 10.1002/asia.202401051. Epub 2024 Nov 29.
Controlled release of singlet oxygen from chemical sources is becoming an interesting path for eliciting apoptotic death of cancer cells. In this work, we present the synthesis and characterization of hitherto unknown class of aromatic endoperoxides, namely quinoline endoperoxides. Quinolines, especially after quaternization, show significant targeting of mitochondria. This leads to more effective cytotoxicity in cancer cell cultures suggesting a potential utility in cancer therapy.
从化学源可控释放单线态氧正成为引发癌细胞凋亡死亡的一条有趣途径。在这项工作中，我们展示了一类迄今未知的芳香族内过氧化物即喹啉内过氧化物的合成与表征。喹啉，尤其是季铵化后，对线粒体有显著的靶向作用。这在癌细胞培养中导致了更有效的细胞毒性，表明其在癌症治疗中具有潜在应用价值。
