Zhang Guangyu, Wang Lei, Qiao Yuan, Sun Rensong, Liu Ziang, Akkaya Engin U
State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Chem Asian J. 2024 Dec 16;19(24):e202400759. doi: 10.1002/asia.202400759. Epub 2024 Nov 7.
Nitric oxide (NO) is an important signaling molecule in both healthy and pathological processes. In this work, we present the first example of a novel class of organic NO-donor compounds with minimal toxicity. The release is driven by the reaction of singlet oxygen spontaneously produced by the cycloreversion reaction of the endoperoxide. Cell culture and imaging data confirms the release of NO in this bimodular system.
一氧化氮（NO）在健康和病理过程中都是一种重要的信号分子。在这项工作中，我们展示了一类新型有机NO供体化合物的首个实例，其毒性极小。释放是由内过氧化物的环化逆转反应自发产生的单线态氧的反应驱动的。细胞培养和成像数据证实了在这个双模块系统中NO的释放。
