Department of Anesthesiology, LeShan Geriatric Specialized Hospital, LeShan, China.
Department of Anesthesiology, Southwest Medical University Hospital, Luzhou, China.
Medicine (Baltimore). 2024 Nov 29;103(48):e40767. doi: 10.1097/MD.0000000000040767.
Folate is a vitamin that is exclusively derived from diet sources. Low folate levels are typically associated with cardiovascular disease, cognitive impairment, and cancer risk. However, few studies have examined the direct relationship between serum folate levels and sleep duration. Accordingly, we aimed to examine the relationship between serum folate levels and sleep duration. Using data from the National Health and Nutrition Examination Survey (NHANES), we examined the association between serum folate levels and sleep duration. We used laboratory data to obtain independent serum folate, and covariate data, including total cholesterol, high-density lipoprotein, blood glucose, and glycated hemoglobin; dependent variable sleep duration and covariate data including race, family income, marital status, education, and country of birth from questionnaire data; and other covariate data such as systolic blood pressure, diastolic blood pressure, waist circumference, and body mass index data from the measured data. Data was primarily analyzed using multiple regression analysis, stratified analysis with interactions, restricted cubic splines (RCS), and threshold effect analysis. A total of 14,072 participants over 19 years of age were enrolled, comprising 6923 (49.2%) males and 7149 (50.8%) females, with a median age of 48 years. The association between serum folate levels and sleep duration exhibited an inverted L-shaped curve (P = .033) in RCS. In the threshold analysis, for participants with serum folate of <32.208 nmol/L (β = 0.608, 95% CI: (0.275, 0.942), P < .001), the sleep duration was significantly increased by 0.608 minutes, with every 1 nmol/L in serum folate increased. At serum folate of ≥32.208 nmol/L, no significant association between serum folate and sleep duration was detected [β = 5.686, 95% CI: (-1.508, 12.88), P = .118]. Our findings revealed an inverted L-shaped relationship and saturation effects between serum folate levels and sleep duration in adults in the United States.
叶酸是一种仅从饮食中获取的维生素。低叶酸水平通常与心血管疾病、认知障碍和癌症风险有关。然而，很少有研究检查血清叶酸水平与睡眠时间之间的直接关系。因此，我们旨在研究血清叶酸水平与睡眠时间之间的关系。我们使用来自国家健康和营养检查调查（NHANES）的数据，研究了血清叶酸水平与睡眠时间之间的关联。我们使用实验室数据获得了独立的血清叶酸，以及协变量数据，包括总胆固醇、高密度脂蛋白、血糖和糖化血红蛋白；依赖变量睡眠时间和协变量数据，包括种族、家庭收入、婚姻状况、教育程度和出生国家，这些数据来自问卷数据；以及其他协变量数据，如收缩压、舒张压、腰围和体重指数数据，这些数据来自测量数据。数据主要使用多元回归分析、分层分析与交互作用、限制立方样条（RCS）和阈值效应分析进行分析。共纳入 14072 名 19 岁以上的参与者，其中 6923 名（49.2%）为男性，7149 名（50.8%）为女性，中位年龄为 48 岁。血清叶酸水平与睡眠时间之间的关系在 RCS 中呈现出倒 L 形曲线（P =.033）。在阈值分析中，对于血清叶酸水平<32.208 nmol/L 的参与者（β=0.608，95%CI：（0.275，0.942），P<0.001），睡眠时间显著增加了 0.608 分钟，每增加 1 nmol/L 血清叶酸。在血清叶酸水平≥32.208 nmol/L 时，血清叶酸与睡眠时间之间没有显著关联[β=5.686，95%CI：（-1.508，12.88），P=.118]。我们的研究结果表明，在美国成年人中，血清叶酸水平与睡眠时间之间存在倒 L 形关系和饱和效应。
