Liao Yuxing, Wang Yilin, Lin YaJie, Xiao Yuxi, Mohan Mohith, Jaman Rummana, Dong Hao, Zhu Jiao, Li Xuerui, Zhang Conglin, Chen Guiyuan, Zhou Jiaqi
School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, China.
College of Clinical Medicine, Dali University, Dali, Yunnan 671000, China.
Ecotoxicol Environ Saf. 2024 Dec;288:117418. doi: 10.1016/j.ecoenv.2024.117418. Epub 2024 Nov 28.
Tetrabromobisphenol A (TBBPA) is a ubiquitous brominated flame retardant extensively incorporated into a wide range of products. As its utilization has escalated, its environmental exposure risks have concomitantly increased. The molecular properties of TBBPA allow it to persist in the environment and within organisms. In this review, we comprehensively examine the toxicity of TBBPA across different organ systems and elucidate the underlying molecular mechanisms. We particularly emphasize TBBPA's impact on biological signaling pathways, protein functionality, cellular architecture, and epigenetic regulation, which collectively lead to disruptions in endocrine, hepatic, neurological, reproductive, and other biological systems. The analysis of these toxicological phenomena and their fundamental molecular mechanisms has substantially enhanced our understanding of TBBPA's hazardous characteristics. This review also examines potential avenues for future research, with a focus on uncovering novel molecular mechanisms and assessing the toxicological impacts of TBBPA exposure, particularly in relation to interactions with other environmental contaminants. We propose a greater focus on examining the toxic effects and molecular mechanisms of long-term TBBPA exposure at environmentally relevant concentrations to facilitate more accurate assessments of human health risks.
四溴双酚A（TBBPA）是一种广泛存在的溴化阻燃剂，被广泛应用于各种产品中。随着其使用量的增加，其对环境的暴露风险也随之上升。TBBPA的分子特性使其能够在环境和生物体内持续存在。在本综述中，我们全面研究了TBBPA在不同器官系统中的毒性，并阐明了其潜在的分子机制。我们特别强调了TBBPA对生物信号通路、蛋白质功能、细胞结构和表观遗传调控的影响，这些影响共同导致了内分泌、肝脏、神经、生殖和其他生物系统的紊乱。对这些毒理学现象及其基本分子机制的分析，极大地增进了我们对TBBPA危害特性的理解。本综述还探讨了未来研究的潜在途径，重点是揭示新的分子机制以及评估TBBPA暴露的毒理学影响，特别是与其他环境污染物相互作用的情况。我们建议更加关注研究环境相关浓度下长期TBBPA暴露的毒性效应和分子机制，以便更准确地评估人类健康风险。
