Glinsukon T, Sinlapanapaporn S, Chulasamaya M
Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):265-8.
Cytochalasins A, B, C, D and E at a concentration of 5.0 microgram/ml significantly inhibited the motility of spermatozoa collected from the cauda epididymidis of rats when diluted in Hank's solution containing BSA by 21.6-38.1% within a few min incubation. The motility was significantly inhibited (approx. 16.7%) by Cyto. E at a concentration as low as 1.0 microgram/ml within 30 min. This inhibitory effect of Cyto. E was a dose-dependent at the concentrations ranging from 1.0-20.0 microgram/ml. These findings demonstrate that cytochalasins are powerful inhibitors on the motility of rat epididymal spermatozoa.
浓度为5.0微克/毫升的细胞松弛素A、B、C、D和E，在含有牛血清白蛋白的汉克溶液中稀释后，能在几分钟的孵育时间内，使从大鼠附睾尾部采集的精子活力显著降低21.6% - 38.1%。细胞松弛素E在浓度低至1.0微克/毫升时，30分钟内就能使精子活力显著降低（约16.7%）。细胞松弛素E在1.0 - 20.0微克/毫升的浓度范围内，其抑制作用呈剂量依赖性。这些发现表明，细胞松弛素是大鼠附睾精子活力的强力抑制剂。
