Mulligan E, Lahiri S, Mokashi A, Matsumoto S, McGregor K H
Respir Physiol. 1986 Mar;63(3):375-82. doi: 10.1016/0034-5687(86)90103-9.
Sixteen cats were studied to test the hypothesis that oxygen chemoreception in the cat aortic body is dependent on the beta-adrenergic mechanism. The chemoreceptor activity was measured from a few aortic chemoreceptor afferents in each cat, anesthetized with alpha-chloralose (60 mg X kg-1). Three types of experiments were conducted. Aortic chemoreceptor responses to steady-state hypoxia (PaO2 range, 100-30 Torr) were measured (a) before and during intravenous infusion of the beta-receptor agonist, isoproterenol (0.5 micrograms X kg-1) in nine spontaneously breathing cats, and (b) before and after intravenous injection of the beta-receptor antagonist, propranolol (1 mg X kg-1) in seven cats which were paralyzed and artificially ventilated. In the third category (c) the stimulatory effect of hypotension on aortic chemoreceptor activity was measured in six of the seven cats in group (b) before and after propranolol injection. Isoproterenol infusion only moderately stimulated aortic chemoreceptor activity. This stimulation was blocked by propranolol. However, propranolol did not attenuate aortic chemoreceptor responses to hypoxia or to hypotension. We conclude that the beta-receptor adrenergic mechanism does not mediate oxygen chemoreception in the cat aortic body.
对16只猫进行了研究，以检验猫主动脉体中的氧化学感受依赖于β-肾上腺素能机制这一假设。用α-氯醛糖（60mg/kg）麻醉每只猫，从少数主动脉化学感受器传入神经测量化学感受器活性。进行了三种类型的实验。在9只自主呼吸的猫中，在静脉输注β受体激动剂异丙肾上腺素（0.5μg/kg）之前和期间，测量主动脉化学感受器对稳态低氧（动脉血氧分压范围为100 - 30 Torr）的反应（a）；在7只瘫痪并进行人工通气的猫中，在静脉注射β受体拮抗剂普萘洛尔（1mg/kg）之前和之后，测量主动脉化学感受器对稳态低氧的反应（b）。在第三类实验（c）中，在普萘洛尔注射之前和之后，测量（b）组7只猫中的6只猫低血压对主动脉化学感受器活性的刺激作用。输注异丙肾上腺素仅适度刺激主动脉化学感受器活性。这种刺激被普萘洛尔阻断。然而，普萘洛尔并未减弱主动脉化学感受器对低氧或低血压的反应。我们得出结论，β受体肾上腺素能机制不介导猫主动脉体中的氧化学感受。
