Zhu Jie-Ying, Guo Liang
School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China 200438; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, China 200438; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, China 200438.
School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai, China 200438; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai, China 200438; Key Laboratory of Exercise and Health Sciences of the Ministry of Education, Shanghai University of Sport, Shanghai, China 200438.
J Adv Res. 2024 Nov 28. doi: 10.1016/j.jare.2024.11.031.
Exercise has received considerable attention because of its importance not just in regulating physiological function, but also in ameliorating multiple pathological processes. Among these processes, lipolysis may play an important role in exercise-induced benefits. It is generally accepted that active lipolysis contributes to breakdown of fats, leading to the release of free fatty acids (FFAs) that serve as an energy source for muscles and other tissues during exercise. However, the significance of lipolysis in the context of exercise has not been fully understood. This review comprehensively outlines the potential regulatory mechanisms by which exercise stimulates lipolysis. The potential roles of exercise-mediated lipolysis in various physiological and pathological processes are also summarized. Additionally, we also discussed the potential non-classical effects of key lipolytic effectors induced by exercise. This will enhance our understanding of how exercise improves lipolytic function to bring about beneficial effects, offering new insights into potential therapeutic avenues for promoting health and alleviating diseases.
运动因其不仅在调节生理功能方面，而且在改善多种病理过程中的重要性而受到了广泛关注。在这些过程中，脂肪分解可能在运动带来的益处中发挥重要作用。人们普遍认为，活跃的脂肪分解有助于脂肪的分解，导致游离脂肪酸（FFAs）的释放，这些游离脂肪酸在运动期间作为肌肉和其他组织的能量来源。然而，脂肪分解在运动背景下的意义尚未得到充分理解。这篇综述全面概述了运动刺激脂肪分解的潜在调节机制。还总结了运动介导的脂肪分解在各种生理和病理过程中的潜在作用。此外，我们还讨论了运动诱导的关键脂肪分解效应物的潜在非经典效应。这将增强我们对运动如何改善脂肪分解功能以产生有益效果的理解，为促进健康和减轻疾病的潜在治疗途径提供新的见解。
